Polycystic Ovary
Conditions
Keywords
polycystic ovary, liraglutide
Brief summary
The aim of this study is to compare the hormonal, metabolic and clinical effects of metformin and liraglutide in infertile women with PCOs.
Detailed description
This prospective randomized clinical trial will be conducted at Gynecology and obstetrics department in Beni Suef University Hospital, Beni suef, Egypt. The trial will be included 150 women with Poly cystic ovary syndrome based on the Rotterdam criteria.
Interventions
DRUGliraglutide
glucagon-like peptide 1 receptor agonist
DRUGMetformin
biguanide antihyperglycemic
Sponsors
Beni-Suef University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
* women aged 18-45 years * Poly cystic ovary syndrome based on the Rotterdam criteria
Exclusion criteria
1. congenital adrenal hyperplasia, 2. poorly controlled thyroid disease 3. Taking antidiabetic drugs which can affect insulin resistance 4. chronic kidney disease 5. liver dysfunction (AST or ALT 6. Documented use of oral hormonal contraceptives and hormone-releasing implants 7. intolerance or allergy to liraglutide or metformin
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Insulin Resistance (HOMA-IR) | 6-months |
Countries
Egypt
Contacts
STUDY_DIRECTORBeni-Suef University
Clinical Pharmacy Faculty of Pharmacy Beni-Suef University
Outcome results
None listed