Gallstone, Gastric Cancer
Conditions
Keywords
Gallstone, Gastric Cancer, Gastrectomy
Brief summary
To provide preventive and therapeutic strategies for participants with gallstones after gastric cancer by comparing the risk of postoperative gallbladder stone formation with two different resection ranges using the Roux-en-Y reconstruction modality in radical gastric cancer surgery.
Detailed description
A large number of clinical studies have found that the incidence of gallstones in patients after radical gastric cancer surgery is higher than that in the normal population. However, the pathogenesis has not been clarified, and the prophylactic removal of the gallbladder in patients with gastric cancer remains controversial. A previous study found a statistically significant incidence of gallbladder stones after Billroth I versus Roux-en-Y in distal gastrectomy for gastric cancer. Therefore, the investigators plan to conduct a retrospected cohort study to collect further participants with gastric cancer who underwent total gastrectomy to answer whether different surgical resection ranges during surgery increase the incidence of gallstones this question.
Interventions
PROCEDUREDistal gastrectomy and radical resection
Distal gastrectomy and Roux-en-Y anastomosis
PROCEDURETotal gastrectomy and radical resection
Total gastrectomy and Roux-en-Y anastomosis
Sponsors
Hepatopancreatobiliary Surgery Institute of Gansu Province
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
Distal gastrectomy and Total gastrectomy
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Patients with Gastric Cancer underwent Gastrectomy
Exclusion criteria
* Age less than 18 years or age greater than 75 years; * Not Roux-en-Y reconstruction; * R0 excision is not achieved; * Previous history of upper abdominal surgery, such as cholecystectomy, gastrectomy; * Preoperative gallbladder diseases, such as gallstones, gallbladder polyps, chronic cholecystitis; * Preoperative neoadjuvant chemotherapy or radiotherapy; * Previous history of malignant tumours; * Patients with mental or developmental abnormalities or women during pregnancy or breastfeeding; * Gastric perforation or bleeding leading to emergency surgery; * Palliative surgical treatment; * Incomplete case information.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of gallstone patients | 5years | Two groups of patients with gastric cancer had a follow-up for more than one year and the number of patients with gallbladder stones on B-ultrasound or Computed Tomography (CT) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Number of patients with postoperative complications | 5years | The number of patients with postoperative complications such as abdominal haemorrhage, fistula, nausea, vomiting, abdominal infection and incision infection in 2 groups of gastric cancer patients |
| Number of patients with bile duct stones | 5years | Two groups of patients with gastric cancer had a follow-up for more than one year. Clinical signs such as Charcot's triad and ultrasound, Computed Tomography (CT) or Magnetic Resonance Imaging (MRI) show the number of patients with bile duct stones |
Countries
China
Outcome results
None listed