Obsessive-Compulsive Disorder
Conditions
Keywords
Obsessive-Compulsive Disorder, OCD, transcranial direct current stimulation, tDCS, Cognitive Behavior Therapy, CBT
Brief summary
This pilot study aims to compare the effect of transcranial direct current stimulation (tDCS) versus sham stimulation, delivered immediately prior to cognitive-behavioral therapy (CBT) for obsessive-compulsive disorder (OCD), on patient-reported outcomes. The investigator hypothesize that patients who receive active stimulation will experience greater improvement in OCD symptoms than those who receive sham stimulation.
Interventions
DEVICEtranscranial direct current stimulation
Current will increase to 1.5 milliamps within 30 seconds and then maintain for 20 minutes
DEVICESham transcranial direct current stimulation
Current will increase up to 1.5 milliamps within 30 seconds and then decrease back down over the next 30 seconds to 0 milliamps; subjects will received 0 milliamps for 20 minutes
Sponsors
Rogers Behavioral Health
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Intervention model description
Participants randomized to either active tDCS stimulation or sham.
Eligibility
Sex/Gender
ALL
Age
18 Years to 55 Years
Healthy volunteers
No
Inclusion criteria
* Primary diagnosis of Obsessive-Compulsive Disorder (OCD) * Resident of state of Wisconsin * Enrolled in OCD Intensive Outpatient Program (IOP) at Rogers Behavioral Health in Oconomowoc, WI * Ability to communicate effectively using written and spoken English
Exclusion criteria
* Metal in the body of any kind (e.g., braces, pacemakers, metal plates or screws, intracranial electrodes, implanted devices/defibrillators, prostheses) * Currently taking medication that reduces seizure threshold (e.g., clomipramine) * Cranial pathologies (e.g., holes, plates) * History of seizure or black-out concussion * Pregnancy * Previous treatment at Rogers Behavioral Health
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in Yale-Brown Obsessive-Compulsive Scale - Self-Report from admission to discharge | Up to 12 weeks |
| Change in Quick Inventory of Depressive Symptomology from admission to discharge | Up to 12 weeks |
Secondary
| Measure | Time frame |
|---|---|
| Change in Quality of life enjoyment and satisfaction questionnaire - short form from admission to discharge | Up to 12 weeks |
| Number of treatment days between admission and discharge | Up to 12 weeks |
| Change in Subjective units of distress from admission to discharge | Up to 12 weeks |
| Change in Intolerance of uncertainty scale from admission to discharge | Up to 12 weeks |
| Change in Obsessive-Compulsive Inventory-Revised from admission to discharge | Up to 12 weeks |
Countries
United States
Outcome results
None listed