Myopia, Refractive Errors, Eye Diseases, Glaucoma, Primary Open Angle, Peripapillary Atrophy
Conditions
Keywords
high myopia, glaucoma, Peripapillary Atrophy, Optical Coherence Tomography
Brief summary
This study intends to analyze the characteristics between peripapillary retinal nerve fiber layer thickness and peripapillary area in high myopia with or without glaucoma
Detailed description
Glaucoma is the leading cause of irreversible blindness in the world. Myopia is a risk factor for glaucoma. With the rising prevalence of both myopia and glaucoma in an ageing population, the occurrence of these two ocular conditions in the same patient is likely to increase. It was estimated that there were 163 million people who have high myopia in 2000, and the population with high myopia would increase to almost one billion (9.8% of the world population) worldwide by 2050. There is often a diagnostic challenge to the clinician, since the detection of glaucomatous optic nerve damage in highly myopic eyes is difficult. Recently, the subclassification of peripapillary area could potentially be used to differentiate myopic eyes with and without glaucoma according to OCT findings. However, the characteristics of peripapillary atrophy have not been fully applied in the diagnosis of high myopia and glaucoma. In view of the above problems, the purpose of this study is to analyze the peripapillary area based on optical coherence tomography and it may be a specific marker for identifying high myopia with primary open angle glaucoma.
Interventions
DIAGNOSTIC_TESTOCT imaging
Image J or Spectralis OCT built-in software package was used to manually locate and measure the area and width of the temporal parapapillary atrophy.
Sponsors
Zhongshan Ophthalmic Center, Sun Yat-sen University
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
1. Age ≥18 years. 2. Equivalent spherical ≤-6D or axial length ≥26.5mm. 3. High myopia with primary open angle glaucoma, such as anterior chamber angle is opening, optic rim defect, RNFL loss, etc. 4. The peripapillary region can be accurately defined Based on OCT.
Exclusion criteria
(1)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Evaluation of circumpapillary retinal nerve fiber layer thickness changes within 12 months | 1 years | The circle with a diameter of 3.46 mm is scanned by Spectralis OCT instrument with the optic disc as the center and the RNFL thickness was calculated by built-in software. |
| Evaluation of the area of the peripapillary area changes within 12 months | 1 year | The results of Spectralis OCT instrument are exported, and used Image J or Spectralis OCT built-in software package to manually locate and measure the area of the temporal parapapillary area |
| Evaluation of the width of the peripapillary area changes within 12 months | 1 year | The results of Spectralis OCT instrument are exported, and used Image J or Spectralis OCT built-in software package to manually locate and measure the width of the temporal parapapillary area |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Best corrected visual acuity | 1 day of enrollment | Best corrected visual acuity after refractive error correction using the ETDRS chart |
| Evaluation of the intraocular pressure changes within 12 mouths | 1 year | IOP is measured by goldmann tonometer. |
| Evaluation of the visual field changes within 12 mouths | 1 year | Assess the degree of visual function damage |
| Demographic characteristics | 1 day of enrollment | Including but not limited to gender, age, duration of illness |
| Evaluation of the fundus changes within 12 months | 1 year | Fundus photography uses kowa fundus camera |
| Ocular anterior segment structure | 1 day of enrollment | The ocular anterior segment structure uses lit-lamp biomicroscope |
| Axial length | 1 day of enrollment | axial length is measured using A-type ultrasound. |
| blood pressure | 1 day of enrollment | Demographic characteristics |
| BMI | 1 day of enrollment | weight (lb) / \[height (in)\]2 |
Countries
China
Contacts
Primary ContactYiqing Li
Backup ContactJinpeng Yang
Outcome results
None listed