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Development of a Transdiagnostic Intervention for Adolescents at Risk for Serious Mental Illness

Development of a Transdiagnostic Intervention for Adolescents at Risk for Serious Mental Illness

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT05962879
Enrollment
70
Registered
2023-07-27
Start date
2024-03-22
Completion date
2027-05-31
Last updated
2026-06-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anxiety Disorders, Depressive Disorder, Psychosocial Functioning, Psychotic Disorders

Brief summary

This research study aims to develop a brief group-based treatment called Resilience Training for Teens, then to test how well it protects high school students with mild symptoms of depression, anxiety, or having unusual feelings from developing mental illnesses.

Interventions

BEHAVIORALResilience Training for Teens

A brief 6-session group-based behavioral intervention for high school aged teenagers at risk of a mental illness.

Sponsors

Massachusetts General Hospital
Lead SponsorOTHER
National Institute of Mental Health (NIMH)
CollaboratorNIH

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender
ALL
Age
14 Years to 19 Years
Healthy volunteers
No

Inclusion criteria

* Currently enrolled in 9th through 12th grade and between the ages of 14 and 19 * Endorsed at least one psychotic experience * Provided contact information * Have a parent or legal guardian who is able and willing to provide written informed consent (if under the age of 18) * Have a parent or legal guardian who is able and willing to participate in a parent session * Competent and willing to provide written informed assent (if under the age of 18) or consent (if age 18 or older) * Able to communicate in English

Exclusion criteria

* Currently prescribed psychotropic medication (not including medications for attention deficit/hyperactivity disorder), regardless of adherence * Currently obtaining psychotherapeutic intervention

Design outcomes

Primary

MeasureTime frameDescription
Structured Interview of Psychosis-risk Syndromes (SIPS)1 yearSubclinical psychotic symptoms that represent a risk of transdiagnostic mental illnesses. This semi-structured interview rates psychotic experiences, general symptoms, and functioning. The SIPS interview assesses positive, negative, disorganized, and general symptoms. The range of the Scale of Psychosis-risk Symptoms (SOPS) is 0-6, with a higher score representing more severe symptoms.

Secondary

MeasureTime frameDescription
Child Behavior Checklist (CBCL)1 yearMental health symptoms in the teen rated by both the teen and the parent/guardian consisting of 113 items. The CBCL rates multiple domains across functioning and psychiatric diagnoses. It is scored on a 3-point Likert scale, with higher scores representing more severe symptoms.
Global Functioning Social and Role Scales1 yearSocial and school/work functioning captured on this scale rated on a 10 point likert scale assessing functional and social functioning separately. Higher ratings represent richer functioning.

Countries

United States

Contacts

CONTACTNicole R DeTore, PhD
ndetore@mgh.harvard.edu617-726-2065

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Jun 12, 2026