Healthy
Conditions
Brief summary
The study will examine whether the benefits of brain stimulation on mental functioning can be enhanced if an individual is actively engaging the target brain networks while receiving brain stimulation. The study includes two separate sessions and people will complete either a cognitive task or a perceptual task while receiving transcranial magnetic stimulation. The study will measure change in brain function with EEG.
Interventions
DEVICEBrain state while receiving TMS
Brain state whilst receiving TMS - cognitive control or perceptual. Repeated measures design, so all participants receive the same procedures.
Sponsors
University of Minnesota
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
NONE
Masking description
No blinding is possible
Intervention model description
Repeated measures design - across two separate sessions (one week apart, counterbalanced between participants), participants will receive transcranial magnetic stimulation (TMS) whilst engaging in either a cognitive control or a perceptual task.
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Age 18 - 65, * healthy controls
Exclusion criteria
* Diagnosed psychiatric disorder * Potential contraindications to EEG (e.g. visible scalp abrasions, non-removable hair extensions and/or hair styling that would impede proper EEG recording) * Potential contraindication to TMS (as identified by the TMS safety screener) * Any previous adverse reaction to TMS or MRI * Diagnosed epilepsy or previously experienced a seizure * Diagnosed neurological condition, such as stroke or tinnitus * Experienced a head trauma that was diagnosed as concussion * Current use of, or recent withdrawal from, medications that can increase the risk of seizure * Currently pregnant * Any metal in the head (excluding mouth) * Any implanted medical device
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Theta-gamma cross frequency coupling | 0-500 ms after each TMS stimulus | A metric of brain function measured with EEG - the coupling of theta oscillation phase with gamma power. This will be measured immediately following the intervention (TMS stimulation). |
| Cortical excitability | 60-300 ms after each TMS stimulus | TMS-evoked potentials will be measured with EEG to examine cortical excitability after TMS. This will be measured immediately following the intervention (TMS stimulation). |
Countries
United States
Outcome results
None listed