Electricity; Effects
Conditions
Brief summary
The purpose of the proposed study is to broaden our understanding on the neural effects of High Definition Transcranial Direct Current Stimulation (HD-tDCS) so that its clinical effects can be further improved.
Detailed description
Normal healthy individuals will be recruited and undergo a standardized neuropsychological assessment (ANAM, MoCA, BDI-II, ToMS, and MAAS) and magnetic resonance imaging (MRI). During MRI, HD-tDCS will be applied. Four different stimulation targets will be investigated, and subjects will be randomly assigned for each target groups or sham group. After HD-tDCS/MRI session, subjects will be re-assessed with standardized neuropsychological tests.
Interventions
HD-tDCS will be provided for 20 minutes for each stimulation with peak intensity of 2mA.
Sponsors
University of Manitoba
Natural Sciences and Engineering Research Council, Canada
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Subject)
Masking description
Randomization will happen after baseline assessment. After-intervention assessment will only consist of self-report and computerized assessment. Participants will not aware of the treatment group that they were assigned to.
Intervention model description
4 active treatment groups + 1 inactive treatment group
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
\- All other than excluded.
Exclusion criteria
* History or susceptibility to any neurological or psychiatric diseases, particularly seizures * abnormal MRI * metal implants or a cardiac pacemaker * pregnant or breastfeeding women
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| change of functional connectivity | 0-11 minutes after the stimulation contrasting baseline (before stimulation) | Changes in seed-based connectivity originating from the targeted brain regions immediately after the brain stimulation |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| change of cerebral blood flow | 12-16 minutes after the stimulation contrasting baseline (before stimulation) | Changes in Cerebral Blood Flow (estimated using pseudo continuous arterial spin labeling ) |
| Toronto Mindfulness Scale (curiosity) | Baseline, then within 1-2 hours from stimulation | mindfulness scale for curiosity. min: 0, max: 30. Higher score means higher curiosity-mindfulness. |
| Toronto Mindfulness Scale (decentering) | Baseline, then within 1-2 hours from stimulation | mindfulness scale for decentering. min: 0, max: 35. Higher score means higher decentering-mindfulness. |
Countries
Canada
Contacts
CONTACTJi Hyun Ko, PhD
Outcome results
None listed