Spinal Cord Tumors
Conditions
Keywords
MRE, Slip Interface Imaging, Glioma, Magnetic Resonance Elastography, Spinal meningioma, Neurofibroma, Ependymoma, Astrocytoma, Glioblastoma, Spinal lipoma
Brief summary
In spinal cord tumors requiring surgical intervention, the resection difficulty is determined by two significant factors: tumor stiffness and adhesion to surrounding tissue. The stiffness of the tumor dictates the complexity of removal, while strong adhesion presents additional challenges during the surgical procedure. This clinical trial aims to assess the clinical utility of magnetic resonance elastography (MRE), in evaluating the stiffness and adhesion of spinal cord tumors and guiding surgical planning to selecting the most appropriate surgical approach for patients with spinal cord tumors.
Detailed description
Spinal cord tumors are a common condition in neurosurgery, including neurofibroma, spinal meningioma, ependymoma, glioma, spinal lipoma, and so on. Magnetic resonance imaging (MRI) plays a crucial role in the preoperative evaluation and planning of spinal cord tumor surgery. It provides detailed information about the tumor's location, size, and relationship to adjacent structures. However, routine MRI may not always provide sufficient information about the tumor's stiffness or adhesion, which can impact surgical planning and postoperative outcomes. Magnetic resonance elastography and slip interface imaging can help measure the mechanical properties of tissues, including their stiffness or adhesion. By combining the above methods, surgeons can identify areas of potential tumor adherence or invasion into surrounding structures, allowing for more precise surgical resection and minimizing the risk of damage to critical neural tissue.
Interventions
DIAGNOSTIC_TESTMagnetic Resonance Elastography
Undergo MRE and routine MRI
PROCEDUREAssessment and Recording
Undergo grading and recording of tumor stiffness and adhesion during surgery
Sponsors
Shengjing Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* All patients undergoing spinal cord tumor resection surgery are eligible for inclusion in the study cohort.
Exclusion criteria
* Patients with metallic implants or foreign bodies in their bodies (pacemakers, artificial metallic heart valves, metal joints, metal implants, and those who cannot remove dentures, insulin pumps, or contraceptive rings) * Pregnant women in the first trimester (within three months) * Patients with severe claustrophobia or anxiety * Patients with severe fever * Patients who can not tolerate MRE * Patients with vascular malformations and aneurysms. * Patients who do not sign an informed consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Surgical assessment of tumor stiffness | Baseline to 6 weeks | The surgeon will score the tumor stiffness in seven aspects, ranging from 1 to 5 points: Tumor size; Shape of tumor; Tumor texture; Stiffness of the tumor's capsule; Stiffness of the tumor's central region; Primary methods of tumor removal; Features of tumor's capsule. |
| Surgical assessment of tumor adhesion | Baseline to 6 weeks | The surgeon will score the tumor's adhesion based on seven aspects, ranging from 1 to 4 points: Stripping instruments; Frequency of use of sharp instruments; Adhesion range; Degree of tumor resection; Cranial nerve anatomy preservation; Brain tissue anatomy preservation; Neurological function (compared with preoperative). |
Countries
China
Contacts
CONTACTYu Shi, MD
CONTACTWen Cheng, MD
PRINCIPAL_INVESTIGATORYu Shi, MD
Shengjing Hospital
PRINCIPAL_INVESTIGATORAnhua Wu, MD
Shengjing Hospital
PRINCIPAL_INVESTIGATORWen Cheng, MD
Shengjing Hospital
Outcome results
None listed