Bipolar I Disorder, Manic Episode
Conditions
Brief summary
This research is being done to find if there are changes with voice and speech during episodes of mania.
Interventions
BEHAVIORALResearch interview
Research interview to capture speech data with high quality cardioid headset microphone
Sponsors
Mayo Clinic
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Provision of informed consent before any study procedures are performed * English speaker * Documented clinical diagnosis for Bipolar I Disorder * Undergoing hospitalization, or boarding in the Emergency Department, for mania as determined by primary clinical staff
Exclusion criteria
* Positive urine drug screen for amphetamines or cocaine. * Expressing paranoid delusions regarding electronic surveillance. * Documented clinical diagnosis of developmental delay. * Currently involuntarily hospitalized. * Deemed at risk for aggression. * Failure to comprehend study objectives via comprehension questionnaire. * Individuals who have a guardian and are unable to consent for themselves. * Current communicable disease requiring isolation.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Acoustic Differences | Approximately 48 hours after taking antimanic medications until up to end of subject participation approximately 1 month from enrollment | The raw audio data will be analyzed for change in pitch, variability of rhythm, and response time. |
| Syntactical Differences | Approximately 48 hours after taking antimanic medications until up to end of subject participation approximately 1 month from enrollment | Audio data will be transcribed using voice to text software and then analyzed for syntactical elements of speech including sentence structure and grammar. |
| Semantic Differences | Approximately 48 hours after taking antimanic medications until up to end of subject participation approximately 1 month from enrollment | Transcribed audio data will be analyzed for changes in verbosity, lexical diversity, and coherence on a sentence and paragraph level. |
Countries
United States
Contacts
PRINCIPAL_INVESTIGATORMark Frye, MD
Mayo Clinic
Outcome results
None listed