Knee Osteoarthritis, Aging and Metabolic Syndrome

What Affects the Severity of Knee Osteoarthritis? Aging or Associated Metabolic Syndrome

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05955573

Enrollment

Registered

2023-07-21

Start date

2023-08-20

Completion date

2024-08-31

Last updated

2024-03-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee Osteoarthritis

Keywords

knee osteoarthritis, Aging, Metabolic Syndrome

Brief summary

Osteoarthritis (OA) is the most prevalent form of arthritis. Its pathogenesis remains poorly understood. Though historically regarded as a disease of mechanical degeneration, it is now appreciated that inflammation plays an important role in OA pathogenesis

Detailed description

1. Place of the study: Sohag university hospital. 2. Type of study: Cross-Sectional Observational study 3. Study period: Six months to one year The study will include Patients who met the American College of Rheumatology (ACR) clinical criteria for knee OA . The following details will be obtained: * Demographic data : Age ,Sex ,Marital status ,Occupation ,Residence ,Education level ,Anthropometrical measures which included waist circumference (WC) and blood pressure (BP) will be obtained,History of chronic diseases (eg; Diabetes mellites, Hypertension) * Clinical information: Symptom and its Duration. Plain radiographs of at least one knee \[anteroposterior (A/P), lateral} will be taken. * Laboratory findings included fasting blood sugar, serum levels of triglycerides, High-density lipoprotein cholesterol and total cholesterol.

Interventions

DIAGNOSTIC_TESTxray

radiological description

Study design

Observational model

CASE_ONLY

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

30 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients who met the American College of Rheumatology (ACR) clinical criteria for knee OA and had symptomatic OA of at least 1 knee (index knee), with a Kellgren / Lawrence (K/L) score ≥ 1 in that knee

Exclusion criteria

* Any patient with a history of trauma to the knee * Any other form of arthritis (e.g., rheumatoid arthritis, seronegative spondyloarthropathies, gout, pyrophosphate disease, or other crystal arthropathy)

Design outcomes

Primary

Measure	Time frame	Description
severity of knee osteoarthritis	8/2023-8/2024	Kellgren and Lawrence (K/L) grading system of Knee osteoarthritis. It assigned a grade from 0 to 4, which they correlated to increasing severity of OA, with Grade 0 signifying no presence of OA and Grade 4 signifying severe OA .

Countries

Egypt

Contacts

Primary ContactAmany Mohamed abdelrahman, master

amanymohamed@med.sohag.edu.eg01066706352

Backup ContactHanan Sayed Abo-zaid, MD

01150532194

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026