Adenomatous Polyps
Conditions
Keywords
familial adenomatous polyposis, Ileoanal pouch/reservoir, adenomas, chromoendoscopy, indigocarmine, colectomy
Brief summary
The detection of adenomas is the basis for the follow-up of patients with familial adenomatous polyposis, after colectomy, with a remnant rectum or an ileal pouch. The optimal method for the adenomas detection is not defined yet. Despite the proven effectiveness of indigo-carmine in different indications dye chromoendoscopy is not used in a consensual way at the international level. The situation of the ileal pouch is specific as adenomas have a usually flat shape and are much more difficult to identify than in the situation of a remnant rectum, even in the situation of \> 5 mm adenomas that should be resected. Our hypothesis is that indigo-carmine can improve adenomas detection, including \> 5 mm adenomas, in patients with a an ileal pouch after colectomy improving the effectiveness of surveillance programs and potentially reducing the risk of cancer in this population.
Interventions
PROCEDUREAdenomas detection rate with the different observation methods
Films performed in white light high definition, NBI and indigo-carmine dye, will be compared blindly to detecte number of adenomas with the different observation methods
Sponsors
Jean Christophe Saurin
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* Patients with familial adenomatous polyposis * Ileo-anal anastomosis with pouch reservoir * Quality of the final preparation = 3 (excellent) on the studied area * Films made under optimal conditions for the 3 staining methods
Exclusion criteria
* Patient with no familial adenomatous polyposis * Patient without Ileo-anal anastomosis reservoir * Insufficient quality of the final preparation \<3 * Absence of films made under optimal conditions for the 3 staining methods
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Average number of ileal pouch/reservoir adenomas | 6 months after colonoscopy | Average number of ileal pouch/reservoir adenomas detected according to the endoscopic mode (staining or not, virtual or not) based on a paired review of the films with final consensus in case of discordance |
Contacts
Primary ContactJean-Christophe SAURIN, Pr
Backup ContactMaira MORENO, PhD
Outcome results
None listed