A Study of Changes in Heart Function and Blood Flow in People Receiving Anesthesia

Changes in Loading Conditions on Induction of General Anesthesia: Mechanisms of Post-Induction Hypotension (PIH)

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05954832

Enrollment

250

Registered

2023-07-20

Start date

2023-07-13

Completion date

2027-07-01

Last updated

2026-08-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anesthesia

Keywords

Changes in Heart Function, Changes in Blood Flow, Echocardiography, 23-079

Brief summary

The purpose of this study is to understand changes in heart function (how the heart pumps blood) and blood flow in people who receive general anesthesia during surgery. The researchers are particularly interested in the heart function and blood flow changes in people who experience low blood pressure (hypotension) after receiving anesthesia.

Interventions

DIAGNOSTIC_TESTEchocardiography

Echocardiography and non-invasive blood pressure (NIBP) cuff to measure blood pressure- in anywhere between 2.5 - 5 minute increments before, immediately after anesthesia induction and after intubation for up to 20 minute.

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Adult patients ≥ 18 years of age requiring general anesthesia for surgery * Intubation required for anesthetic management / surgery * Anticipated prep time before incision of 20 minutes * Baseline MAP \>70mmHg

Exclusion criteria

* History of coronary artery disease * History of cardiac disease (e.g., HTN, arrythmias, valvular and structural abnormalities) * History of peripheral artery occlusive disease * Beta-blocker use * Anti-hypertensive medication use * Patients with epidural, spinal, paravertebral, serratus blocks preoperatively * Patients requiring rapid sequence induction (where intubation occurs concurrently with induction) * Emergency surgery

Design outcomes

Primary

Measure	Time frame	Description
The proportion of patients with post-induction hypotension (PIH)	up to 20-mins after anesthesia induction.	summarize the distributions of the echocardiography parameter values (pre-load LVEDd(cm), after-load LVEDs(cm), other measures \[e.g., contractility (EF %) and structural abnormalities\]) across each timepoint among patients with and without PIH

Countries

United States

Contacts

CONTACTAnahita Dabo-Trubelja, MD

daboa@mskcc.org212-639-3279

CONTACTGregory Fischer, MD

212-639-2581

PRINCIPAL_INVESTIGATORAnahita Dabo-Trubelja, MD

Memorial Sloan Kettering Cancer Center

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Aug 11, 2026