PRactice of Ventilation and Adjunctive Therapies in COVID-19 Patients.

PRactice of Ventilation and Adjunctive Therapies in COVID-19 Patients; What is the Optimal Ventilation Strategy in Critically Ill COVID-19 Patients, in Particular PEEP and the Moment of Switch to Pressure Support?

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05954351

Acronym

PRoVAcT-COVID

Enrollment

2465

Registered

2023-07-20

Start date

2022-05-01

Completion date

2023-07-01

Last updated

2024-07-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

COVID-19 Acute Respiratory Distress Syndrome

Brief summary

PRactice of Ventilation and Adjunctive Therapies in COVID-19 Patients. An observational study of ventilation practice and adjunctive therapies in critically ill, invasively ventilated COVID-19 patients during the first and second surge of COVID-19 in the Netherlands.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 120 Years

Healthy volunteers

Inclusion criteria

* receiving invasive ventilation or high-flow nasal oxygen for COVID-19 for SARS-CoV-2 * admitted to one of the ICUs of the participating hospitals

Exclusion criteria

* none

Design outcomes

Primary

Measure	Time frame
ICU mortality	90 days from inclusion

Secondary

Measure	Time frame
Duration of ventilation	90 days from inclusion
28-day ventilator free days	90 days from inclusion
28-day, 90-day mortality	90 days from inclusion
ICU and hospital length of stay	90 days from inclusion

Other

Measure	Time frame
pneumothorax and thromboembolic complications	90 days from inclusion
Acute kidney injury	90 days from inclusion
use of immunomodulating drugs	90 days from inclusion
duration of ventilation in survivors	90 days from inclusion
use of muscle paralysis	90 days from inclusion
vasopressor or inotrope administration	90 days from inclusion
occurrence of tracheostomy	90 days from inclusion

Countries

Netherlands

Outcome results