Autoimmune Encephalitis, Autoimmune Encephalitis Caused by N-Methyl D-Aspartate Receptor Antibody (Disorder)
Conditions
Keywords
Diagnostic score, auto-immune encephalitis
Brief summary
The investigators wish to test a diagnostic risk score for autoimmune encephalitis in case of encephalitis, previously validated by two American teams, in a retrospective analysis, according to the clinical and paraclinical data available in our database of the Reference Centre for Autoimmune Encephalitis and Paraneoplastic Neurological Syndromes of Professor Honnorat for patients with NMDAr, anti LGi1, anti CASPR2, anti GABAbr and anti GAD antibodies.
Interventions
OTHERClinical score of Granillo and al.
Compare the performance of the clinical prediction score of confirmed autoimmune encephalitis according to the type of antibody isolated from the CSF.
Sponsors
Hospices Civils de Lyon
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age \> 18 years old * Patient with a definite auto-immune encephalitis (Graus and al. 2016)
Exclusion criteria
* Uncomplete data in acute phase * Patient with several antibodies * Opposition
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Validation of a diagnostic score for encephalitis to assess the risk of autoimmune origin. | At baseline | Comorbidities assessed by the Charlson score |
| Symptoms in the acute phase | At baseline | — |
| Mode of onset of disease | At baseline | — |
| Results of lumbar puncture | At baseline | — |
| Results of antineuronal antibodies in CSF | At baseline | — |
| Results of antineuronal antibodies in serum | At baseline | — |
Countries
France
Outcome results
None listed