Hemodialysis Catheter-Associated Bacteremia, Hemodialysis Complication
Conditions
Brief summary
The aim of this study is to examine the effect of ethanol (70%) as lock-solution after hemodialysis on: * The frequency of dialysis catheter-related bacteremia among patients under observation of potential complications * Other complications of the use of hemodialysis-catheters eg. dysfunction of the catheter due to thrombosis.
Interventions
DRUGEthanol 70%
Once a week, the catheter will be closed with 3 mL ethanol 70% lock-solution after a completed hemodialysis. The fluid will stay in the catheter until next hemodialysis (ca. 48 hours). The fluid will be aspirated before the hemodialysis. Standard lock-solution of isotonic saline with heparin will be used for the remaining two hemodialysis procedures of the week.
DRUGIsotonic saline with heparin
Standard procedure of isotonic saline used as lock-fluid after completed hemodialysis.
Sponsors
Zealand University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age at or above 18 years. * Currently recieving hemodialysis treatment with tunneled intravenous hemodialysis-catheter * Written informed consent after verbal and written information is given.
Exclusion criteria
* Pregnancy or breastfeeding * Intolerance to ethanol or contraindications for the use of ethanol. Eg. possible interactions, former alcohol dependency. * Earlier infections to current catheter (exit-site, tunnel-infection and catheter-related bloodstream infection
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time to hemodialysis catheter-related bacteremia | 2 years |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Time to exit-site infection | 2 years | days |
| Time to removal of catheter due to infection | 2 years | days |
| Incidence of hemodialysis catheter-related bacteremia | 2 years | number per year |
| Life quality | 2 years | score of QOL questionaire |
| Economical costs | 2 years | Cost af treatment and cost of complications per patient year compared |
| Complications eg. catheter-thrombosis and pulmonary embolus | 2 years | number per year |
Countries
Denmark
Outcome results
None listed