Retinal and Choroidal Microvascular Parameters in School-age Children in a COVID-19 Infection Pandemic Peak in China

Optical Coherence Tomography Angiography Evaluation of Retinal and Choroidal Microvascular Parameters in School-age Children in a COVID-19 Infection Pandemic Peak in China

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05952466

Enrollment

100

Registered

2023-07-19

Start date

2023-02-01

Completion date

2023-03-31

Last updated

2023-07-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

COVID-19 Pandemic

Keywords

COVID-19 infection, retinal microvascular involvement, choroidal thickness, school-age children

Brief summary

We designed this study to examine whether COVID-19 infection could lead to retinal and choroidal microvascular involvement in school-age children (6-18 years) in a pandemic peak in China.

Detailed description

This is an observational case-control study. One hundred school-age children who visited the Department of Ophthalmology at Guangzhou First People's Hospital in China from February 1, 2023 to March 31, 2023 were included in this study. Eighty children with COVID-19 infection were included in the case group. Controls without COVID-19 infection were matched to COVID-19 infection cases by a ratio of 1:4 using frequency matching on age and gender. The primary end point of this study is the retinal and choroidal microvascular changes in school-age children during the COVID-19 pandemic. Secondary endpoint is the

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

6 Years to 18 Years

Healthy volunteers

Inclusion criteria

Totally 100 school-age children (6-18 years) were enrolled in this study. All subjects had visited the ophthalmology clinic for routine ocular examinations. Refraction after ciliary muscle paralysis, myopia ≥ -6.0 spherical diopter, astigmatism ≤ 2.5 cylindrical diopter.

Exclusion criteria

1. The child or guardian did not agree to participate in the study. 2. Children could cooperate to complete the ocular examination. 3. The child had previous diseases affecting visual function and fundus, except for the diagnosis of refractive error.

Design outcomes

Primary

Measure	Time frame	Description
Macular and peripapillary blood perfusion density	5 minutes	The blood flow density represents the proportion of the blood flow signal area in the scanning area to the overall area, expressed in units of mm-1, which can show the blood vessel perfusion and circulation.
Macular and peripapillary retinal thickness	3 minutes	Macular fovea and peripheral retinal thickness, retinal thickness around the optic nerve

Secondary

Measure	Time frame	Description
Fundus lesions	2 minutes	Such as fundus hemorrhage, exudation, vascular tortuous expansion, etc.
Vascular distribution shape in macular area	2 minutes	The measurement parameters of the foveal avascular zone include area, perimeter and non-circular index

Countries

China

Outcome results