Colorectal Cancer
Conditions
Brief summary
Anesthetic method was reported to have an impact on postoperative long-term outcome in cancer patients. In this study, we will investigate the effect of different anesthetic methods on NK cell activity, cytokine response and postoperative outcome in colorectal cancer patients undergoing CRS and HIPEC. We will compare propofol-based total intravenous anesthesia (TIVA) with balanced anesthesia to determine the effect of propofol, inhalation agent, and opioid on tumor genesis, recurrence, NK cell activity, cytokine response, and postoperative outcome.
Interventions
DRUGanesthetic method
Patients will be assigned to one of the groups, TIVA group or Balanced anesthesia group. In TIVA group, anesthesia will be maintained by propofol and remifentanil infusion under target controlled infusion. In contrast, anesthesia will be maintained by sevoflurane and remifentanil infusion in the balanced anesthesia group.
Sponsors
Gangnam Severance Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
20 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
1. Colorectal cancer patients undergoing elective cytoreductive surgery and HIPEC (20-70 yrs old) 2. American Society of Anesthesiologists physical status I, II, III
Exclusion criteria
1. Patients under 20 years old. 2. Patients with long-term steroid therapy or immunosuppressive therapy. 3. Patients with long-term NSAIDs therapy. 4. Patients who cannot communicate with other person or with cognitive disorder. 5. Patients who cannot read the consent form.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Postoperative immune function (NK cell count) | Postoperative day 1 | Postoperative immune function will be measured at baseline, POD#1, and POD#7. Postoperative immune function will be investigated by measuring NK cell count. |
Outcome results
None listed