Erosive Oral Lichen Planus
Conditions
Brief summary
this study evaluates the effect of diode laser in treatment of oral lichen planus.
Detailed description
44 patients with erosive oral lichen planus were included in the study and divided into 2 equal groups. Group I received topical steroid therapy three times daily for 4 weeks and antifungal oral gel once daily for 1 week. Group II received 980nm Diode Laser 300 mW, up to 10 sessions.
Interventions
DEVICE980nm Diode Laser
300 mW, 4 J/cm2, 2mm non-contact mode up to 10 sessions
three times daily for 4 weeks
Sponsors
Alexandria University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Masking description
the patients were randomly assigned to avoid bios.
Eligibility
Sex/Gender
ALL
Age
30 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Patient histologically diagnosed with erosive OLP based on WHO modified criteria 2003. * Presence of painful erosive OLP lesions diagnosed by biopsy
Exclusion criteria
* Pregnant or breast-feeding women * Patients currently treated for cancer with Chemotherapy or Radiotherapy * Patient currently on Corticosteroid therapy or had this treatment on the past 3 months * Those who had used Anti-inflammatory drugs topical or systemic in the last month * the use of drugs related to Oral Lichenoid Lesions * Presence of Amalgam restorations near the OLP lesions * dysplasia in histopathological examination * uncontrolled systemic diseases * physical or mental abnormality which would interfere with or be affected by the study procedure * Patients with skin lesion
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| change of pain from the base line to 12 weeks follow-up | base line, 6weeks and 12 weeks | Vas is one way to express pain into a numerical value where 0 means no pain and 10 means worst pain ever |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| change of clinical score of the lesion from the base line to 12 weeks follow-up | base line, 6weeks and 12 weeks | The size of the lesion is monitored where score 0 no lesions, score 1 : mild white striation only, score 2 : white striation with erythematous area \< 1 cm 2, score 3 : white striation with erythematous area \> 1 cm 2, score 4 : white striation \< 1 cm2, score 5 : white striation with erosive area \> 1 cm2. |
Other
| Measure | Time frame | Description |
|---|---|---|
| change in lipid peroxidation marker malondialdehyde from the base line to 12 weeks follow-up o 10 points VAS | base line, 6weeks and 12 weeks | malondialdehyde is a strong marker for lipid peroxidation that can be measured in saliva to assess the effect of the treatment in oral lichen planus |
Countries
Egypt
Outcome results
None listed