Intensive Care Unit Delirium
Conditions
Keywords
Delirium, Intensive Care Unit, Non-pharmacological intervention
Brief summary
This study was designed to evaluate the impact of non-pharmacological multimodal interventions including ongoing orientation, sensory correction, setting of familiar circumstance and promotion of sleep enviromnet for prevention of delirium in intensive care unit.
Detailed description
Delirium significantly increases not only the length of the intensive care unit stay and overall mortality, but also the likelihood of persistant cognitive impairment after recovery. However there is no definitive treatment for delirium, thereby it is important to prevent delirium before it occur. Researches also have focused on the prevention of delirium or the reduction of duration of delirium. Several studies evaluated the effect of non-pharmacological treatment, such as improvement of orientation, prevention of sensory deprivation, active pain control and prevention of dehydration, to reduce the occurrence of delirium and the results were inconsistent depending on the patients included. However, there have been no randomized clinical trials that have tested the effect of prevention of delirium by applying non-pharmacological multimodal approaches in the intensive care unit for Korean patients. A randomized controlled trial was planned to evaluate the impact of on-pharmacological multimodal interventions including ongoing orientation, sensory correction, setting of familiar circumstance and promotion of sleep enviromnet for prevention of delirium in intensive care unit in Korea.
Interventions
OTHERMultimodal therapy for prevention of delirium
Multimodal therapy for prevention of delirium
Sponsors
Seoul National University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
50 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adult patients over 50 years who are expected to spend more than 24 hours in the intensive care unit
Exclusion criteria
* Patients who developed delirium before entering the intensive care unit * Patients with cognitive impairment * Patients who have hearing or vision deficits, or have difficulty in communication * Patients who are expected to die within 24 hours or do not want life-sustaining treatment
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of patients with delirium | From ICU admission up to day 28 or discharge from ICU or death | Delirium assessed by Confusion Assessment Method for the ICU (CAM-ICU) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Delirium-free days | From ICU admission up to day 28 or discharge from ICU or death | Delirium assessed by Confusion Assessment Method for the ICU (CAM-ICU) |
| Severity of delirium | From ICU admission up to day 28 or discharge from ICU or death | Confusion Assessment Method for the ICU-7 (CAM-ICU-7) delirium severity score |
| Accidental extubation or disconnection of treatment devices | From ICU admission up to day 28 or discharge from ICU or death | Accidental extubation or disconnection of treatment devices |
| ICU and hospital length of stay | From ICU admission up to day 28 or discharge from ICU or death | Duration of ICU and hospital stay |
Countries
South Korea
Contacts
CONTACTLeerang Lim, MD
CONTACTHo Geol Ryu, MD, PhD
STUDY_CHAIRHo Geol Ryu, MD, PhD
Seoul National University Hospital
Outcome results
None listed