Extraction of the Lower Third Molars
Conditions
Brief summary
Patients will undergo a split-mouth protocol which includes: a control group: in which the extraction of the lower third molar will be performed according to the standard protocols of the structure. A study group: in which ozone will be used in addition, in two formulations: gaseous, injected into the site of the pre- and post-surgery operation, and topical, in the form of a gel, applied at the end of the operation and for home use according to therapeutic scheme prescribed at the time of discharge. Primary objective: To evaluate whether the use of ozone in patients undergoing extraction of impacted third molars reduces post-operative pain 7 days after surgery. Secondary objectives: * Evaluate the functional limitation in opening the mouth (trismus) 7 days after surgery. * Evaluate if there is a reduced intake of analgesic drugs in the 7 days following the operation. * Evaluate the perceived quality of life in the 7 days following the intervention.
Detailed description
Patients will undergo a split-mouth protocol which includes: a control group: in which the extraction of the lower third molar will be performed according to the standard protocols of the structure. A study group: in which ozone will be used in addition, in two formulations: gaseous, injected into the site of the pre- and post-surgery operation, and topical, in the form of a gel, applied at the end of the operation and for home use according to therapeutic scheme prescribed at the time of discharge. Primary objective: To evaluate whether the use of ozone in patients undergoing extraction of impacted third molars reduces post-operative pain 7 days after surgery. Secondary objectives: * Evaluate the functional limitation in opening the mouth (trismus) 7 days after surgery. * Evaluate if there is a reduced intake of analgesic drugs in the 7 days following the operation. * Evaluate the perceived quality of life in the 7 days following the intervention.
Interventions
OTHERozone therapy
Ozone in the gaseous state produced by a machine at concentrations for medical use (sssssssssss9) injected after anesthesia in the surgery site and in the post-extraction alveolus after suture. * Topical ozone in the form of a gel (indicate the brand) to be applied to the post-surgical site 2 times a day for 7 days.
Sponsors
Azienda Ospedaliera Ordine Mauriziano di Torino
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 30 Years
Healthy volunteers
No
Inclusion criteria
* Lower third molars included * Pell-Gregory Class II-B * Absence of systemic diseases
Exclusion criteria
* Hyperthyroidism; * G6PHD (glucose 6 phosphate dehydrogenase) deficiency; * Anemia * Myasthenia * Pregnancy and breastfeeding * Allergy to ozone * Local infections
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Reduction post operative pain | 7 days | Evaluate whether the use of ozone in patients undergoing extraction of impacted third molars reduces post-operative pain 7 days after surgery. |
Countries
Italy
Contacts
Primary ContactPaolo Appendino, Dr.
Backup ContactLucia Borsotti, dr.ssa
Outcome results
None listed