Safety and Efficacy of High Flow Nasal Canula in Patients With Mild Hypercapnia

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05948527

Enrollment

Registered

2023-07-17

Start date

2023-01-01

Completion date

2023-07-01

Last updated

2023-07-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypercapnia

Keywords

hypercapnia, high flow nasal canula

Brief summary

Evaluate safety and efficacy of application ( high flow nasal canula) in cases with mild hypercapnia, included 30 patients who were hospitalized in Mansoura University chest department with mild Hypercapnia (Pco2 range 45-60 mmhg and power of hydrogen not less 7.30) of different pulmonary disease categories (Chronic obstructive pulmonary disease acute exacerbation, pneumonia, Interstitial lung diseases, etc).

Interventions

DEVICEhigh flow nasal canula

administration of high flow nasal canula at initial flow 35 liters per minute and Fio2 (fraction of inspired oxygen of 50%) with titration to reach oxygen saturation of 88-92%.

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

OTHER

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 75 Years

Healthy volunteers

Inclusion criteria

* patients with mild Hypercapnia

Exclusion criteria

* Excluded cases had age less than 18 years or pediatric group . * patients with their mental state altered, confused, comatose, severe agitation or non cooperative * Cases with moderate or severe Hypercapnia * cases in need for immediate invasive mechanical ventilation * cases with respiratory rate more than 35 breath per minute. * cases with Respiratory exhaustion , fatigue , excess use of respiratory accessory muscles * Shock , hemodynamic instability, post arrest cases, * cases with facial trauma or severe nasal deformity, * Patients with sleep breathing disorders or upper airway obstruction * patients with history of home ventilation prior admission

Design outcomes

Primary

Measure	Time frame	Description
Arterial Blood Gases changes	48 hours	The primary outcome was concerned about changes in Arterial Blood Gases in first 24 h after admission and the same changes 48 h after admission.

Secondary

Measure	Time frame	Description
Number of participants in need for ventilation	7 days	Secondary outcome was concerned about need to non invasive mechanical ventilation or invasive mechanical ventilation.

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 8, 2026