White Spot Lesions
Conditions
Keywords
white spot lesions, orthodontic treatment, Prevention, bioactive gel
Brief summary
white spot lesions are a common problem and are reported in up to 96% of orthodontic patients. In this study, the preventive effect of bioactive gel is evaluated in comparison to fluoride.
Detailed description
Dental caries is a chronic infectious disease present worldwide and is among one of the most common oral diseases. It is a multifactorial disease resulting from imbalance between demineralization and remineralization initiated by acid producing bacteria in the microenvironment. The incipient form of caries, white spot lesions (WSL), is characterized by primitive enamel surface and subsurface demineralization and could be identified clinically by their chalky white appearance . Orthodontic treatment is a major risk factor for the development of WSL. They are reported in up to 96% of orthodontic patients. Many materials are being used to prevent white spot lesions with fluoride being the most commonly used . New materials have been emerged such as giomer based bioactive gel with the ability to release six ions Fluoride inhibits demineralization and promotes deposition of fluoroapatite. Aluminum helps to decrease demineralization as well by forming Alumino fluoro complexes. Borate reduces biofilm formation beside its antibacterial effect. Silica promotes remineralization by inducing apatite nucleation on the tooth surface. Strontium converts hydroxyapatite into strontium apatite thus increasing acid resistance and has an inhibitory effect on bacterial growth. Other ions such as Na act as strong base and have acid buffer capacity.
Interventions
DRUGgiomer based bioactive gel
Application of bioactive gel to prevent white spot lesions in orthodontic patients
DRUGFluoride gel
Application of fluoride gel to prevent white spot lesions in orthodontic patients
Sponsors
Cairo University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Outcomes Assessor)
Masking description
double
Eligibility
Sex/Gender
ALL
Age
15 Years to 28 Years
Healthy volunteers
Yes
Inclusion criteria
* Patients assigned for orthodontic treatment with fixed appliances * Sound teeth with fixed orthodontic appliances * Either maxillary or mandibular teeth or both
Exclusion criteria
* Patients with poor oral hygiene * Allergic reaction to the materials used. * Lack of compliance. * xerostomia * Evidence of parafunctional habits. * Active carious lesions * Dental fluorosis * Hypocalcified teeth * Systemic diseases affecting teeth such as Amelogenesis imperfecta * Severe periodontal affection
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| incidence of white spot lesions using DIAGNOdent | Baseline,change from baseline at 3 months,6 months,9 months and 12 months | the ability of the gels to prevent white spot lesions will be assessed using DIAGNOdent |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| incidence of white spot lesions using ICDAS (international caries detection and assessment system) | Baseline,change from baseline at 3 months,6 months,9 months and 12 months | the ability of the gels to prevent white spot lesions will be assessed using ICDAS |
Outcome results
None listed