Pre-operative 5% Dextrose Infusion & PONV

Is Pre-operative Infusion of 5% Dextrose Effective in Reducing the Incidence of PONV in Middle Ear Surgery? A Blinded Randomized Control Trial

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05947981

Enrollment

105

Registered

2023-07-17

Start date

2023-10-01

Completion date

2024-01-31

Last updated

2024-03-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nausea, Postoperative

Brief summary

With this study, we aim to compare the efficacy of pre-operative dextrose-containing fluid infusion with other fluid for the prevention of PONV in middle ear surgeries.

Detailed description

We hypothesized that maintenance of stable level of blood glucose in addition to adequate hydration through preoperative intravenous dextrose 5% infusion will have a rule in decreasing the incidence and severity of PONV; as it reduces insulin resistance and decreases gastric acid secretion; which may contribute to PONV.

Interventions

DIETARY_SUPPLEMENTDextrose 5%, normal saline

Decrease fasting hours

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

20 Years to 60 Years

Healthy volunteers

Yes

Inclusion criteria

* ASA physical status I and ll. * Patients undergoing middle ear surgeries, mastoidectomy, or tympanoplasty

Exclusion criteria

* history of dependence or use of antiemetics * history of motion sickness * presence of psychiatric illness * pregnant and lactating women * cardiovascular disorders (Ischemic heart diseases, congestive heart failure and valvular diseases) * Diabetic patients

Design outcomes

Primary

Measure	Time frame	Description
PONV	24 hours	incidence

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026