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Testing the ETM: Examination and Comparison of Different Methods

Testing the Experimental Tobacco Marketplace: Examination and Comparison of Different Methods

Status
Completed
Phases
Early Phase 1
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT05946031
Enrollment
87
Registered
2023-07-14
Start date
2024-12-02
Completion date
2025-08-15
Last updated
2026-06-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cigarette Smoking

Brief summary

This study will experimentally assess the comparability of in-lab and remote procedures with hypothetical and real ETM purchase outcomes.

Detailed description

In a between-group within-subject repeated measures design, participants will be randomly assigned to one of two procedures (in-lab or remote; between-group) and complete two conditions (real and hypothetical; within-subject), which include six trials assessing increasing cigarette prices.

Interventions

DRUGReat ETM

Exclusive cigarette smokers will be recruited and will be exposed to the real ETM condition in which tobacco purchases are real and they receive products from one randomly selected trial.

DRUGHypothetical ETM

Exclusive cigarette smokers will be recruited and will be exposed to the hypothetical ETM condition in which tobacco purchases are hypothetical and they don't receive any products.

Sponsors

Virginia Polytechnic Institute and State University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
NONE

Intervention model description

Participants will complete two Experimental Marketplace conditions, representing one with real and one with hypothetical purchasing outcomes. Within each condition, taxes will be increased proportionally across 6 trials to examine how cigarette purchasing, substitution, and poly-tobacco purchasing (i.e., diversity in products purchased) are affected.

Eligibility

Sex/Gender
ALL
Age
21 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Provide informed consent * Be at least 21 years of age or older * Stable tobacco use patterns for at least three months * Smoke at least 5 cigarettes daily * Use other tobacco products less than weekly * Have access to a computer and internet

Exclusion criteria

* report uncontrolled physical or mental health conditions (e.g., uncontrolled diabetes, high blood pressure, major depressive disorder, etc.), * use of smoking cessation medications (e.g., nicotine replacement, bupropion, varenicline) in the past 30 days, * report concrete, immediate plans to alter/quit using their usual tobacco products in the next 30 days, * be pregnant or lactating

Design outcomes

Primary

MeasureTime frameDescription
Cigarette demand1 dayParticipants will complete purchasing trials in an Experimental Tobacco Marketplace (ETM) with cigarettes increasing in price. Other product prices in the ETM will remain constant. To obtain dependent measures of demand, participants' purchasing of the price-manipulated commodity in the ETM task will be fit to a modified exponential equation to quantify the relationship between the price of each commodity and purchasing: Q=Q0\*10k(exp(-αQ0C)-1) where Q is purchasing of the commodity, C is the price, Q0 is the derived initial purchasing without cost constraints (demand intensity), k is the span of the function in logarithmic units, and α is the demand elasticity.
Nicotine/tobacco products substitution1 dayParticipants will complete purchasing trials in an Experimental Tobacco Marketplace (ETM) with cigarettes increasing in price. Other product prices in the ETM will remain constant. To obtain estimates of substitution of price-constant products in the different ETM conditions, the investigators will use ordinary least squares regression to model the relationship of the price-manipulated product to predict total quantity purchased of the price-constant product.

Countries

United States

Contacts

PRINCIPAL_INVESTIGATORJeffrey Stein, Ph.D.

Fralin Biomedical Research Institute at VTC

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Jun 6, 2026