Effects of Acute Grape Seed Extract Supplementation on Muscle Metaboreflex in Healthy Young Individuals

Effects of Acute Grape Seed Extract Supplementation on Muscle Metaboreflex in Healthy

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05945771

Enrollment

Registered

2023-07-14

Start date

2022-05-01

Completion date

2022-08-31

Last updated

2023-07-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dietary Supplementation

Brief summary

The aim of this study was to determine whether grape seed extract (GSE) supplementation could reduce the blood pressure (BP) in response to static exercise and post exercise muscular ischemia (PEMI) in normotensive young adults. In 12 healthy subjects (7 male and 5 female, 24.6±3.4 yr), we compared acute effect of both GSE (600 mg) and placebo (PL: 600 mg) on changes from rest in systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP), heart rate (HR), stroke volume (SV), cardiac output (CO), and total peripheral resistance (TPR) during static exercise (SE) and PEMI. Subjects completed 2 min of SE at 30% of maximal voluntary contraction (MVC) followed by 2 min of PEMI.

Interventions

DIETARY_SUPPLEMENTGrape seed extract

Acute effect of dietary supplementation with GSE on hemodynamic responses during static exercise and muscle metaboreflex and during cycling exercise.

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

PREVENTION

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to 30 Years

Healthy volunteers

Yes

Inclusion criteria

* Healthy volunteers (SBP \< 120 mmHg, DBP \< 80 mmHg)

Exclusion criteria

* cardiovascular and/or pulmonary disease, * musculoskeletal disorders * medications that prevent the safe completion of the exercise protocol

Design outcomes

Primary

Measure	Time frame	Description
Systolic blood pressure (mmHg) by sphygmomanometer	24 hours	Measured from the brachial artery
Diastolic blood pressure (mmHg) by sphygmomanometer	24 hours	Measured from the brachial artery
Mean arterial pressure (mmHg)	24 hours	calculated (MAP = (SBP-DBP)/3 + DBP
Heart rate (bpm)	24 hours	measured using Physio Flow (non-invasive device)
Stroke volume (ml)	24 hours	measured using Physio Flow (non-invasive device)
Cardiac output (l/min)	24 hours	calculated: HR (bpm) x SV (ml)
Total peripheral resistance (mmHg/l/min)	24 hours	calculated: MAP (mmHg) / CO (l/min)

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026