Bronchopulmonary Dysplasia, Vitamin D Overdose
Conditions
Keywords
vitamin D, Overdoses, Bronchopulmonary Dysplasia, Preterm infants
Brief summary
Several studies have demonstrated that vitamin D deficiency at birth is a risk factor of bronchopulmonary dysplasia. However, in an animal model of bronchopulmonary dysplasia vitamin D overdose has also been associated with an increased mortality and an increased lung injury. Such vitamin D overdose has been frequently reported in hospitalized neonates receiving the current supplementation. The hypothesis is that vitamin D overdose is an independent risk factor of bronchopulmonary dysplasia or death among infants born below 31 weeks gestational age excluding infants with vitamin D deficiency. This retrospective cohort study will include all infants born before 31 weeks of gestation (WG), who were hospitalized in a tertiary neonatal intensive care unit (NICU) during at least 10 days, for who at least one 25OH vitamin D determination was performed before 36 WG corrected age and whose parents are not opposed to the study. A descriptive analysis of the cohort depending on the occurrence of vitamin D overdose will be performed. A multivariate analysis will determine if vitamin D overdose is an independent risk factor of bronchopulmonary dysplasia or death among preterm infants, adjusting on the covariates known to be associated with bronchopulmonary dysplasia.
Interventions
BIOLOGICALIs 25 OH vitamin D overdose a risk factor of bronchopulmonary dysplasia or death ?
Vitamin D overdose is frequent among preterm infants receiving the current supplementation (Mauras 2022, Kołodziejczyk-Nowotarska 2021). In our NICU, the protocol was to daily administrate 55 UI vitamin D during parenteral nutrition then 1000 UI during enteral nutrition for babies weighing more than 1000 g and 1200UI during enteral nutrition for babies weighing less than 1000 g. The dosage was adapted each month after a plasmatic measure of 25OH-D in order to maintain 25OH-D between 50 nmol/L and 120 nmol/L.
Sponsors
Hospices Civils de Lyon
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
23 Weeks to 31 Weeks
Healthy volunteers
No
Inclusion criteria
* Inclusion Criteria \* : * Infant born before 31 weeks of gestation. * hospitalized in the NICU during at least 10 days * with at least a 25OH-D determination available before 36 weeks corrected age
Exclusion criteria
-Infant with at least a 25OH-D below 50 nmol/L
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Bronchopulmonary dysplasia or death | The outcome will be assessed at 36 weeks corrected age. | Bronchopulmonary dysplasia is defined as any respiratory support or oxygen requirement at 36 weeks corrected age. |
Countries
France
Outcome results
None listed