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Optic Nerve Sheath Diameter is Associated With Postoperative Delirium in Patients Undergoing Open Heart Surgery

The Relationship Between Optic Nerve Sheath Diameter and Postoperative Delirium in Open Heart Surgery

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT05942183
Enrollment
90
Registered
2023-07-12
Start date
2023-08-07
Completion date
2024-06-12
Last updated
2024-09-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiac Disease, Cardiac Valve Disease, Delirium, Postoperative

Keywords

optic nerve sheath diameter, cardiac surgery, ultrasound

Brief summary

Although the incidence of delirium after cardiac surgery is high, it is not sufficiently recognized. The long-term effects of delirium are likely to be underestimated. In this study, the investigators aimed to examine the relationship between optic nerve sheath diameter and postoperative delirium in open hearth surgery.

Detailed description

Postoperative delirium is characterized by widespread brain involvement and its incidence is between 6% and 30%. It appears twice as often after cardiac and vascular surgery than other types of surgery. The correlation between optic nerve sheath diameter (ONSD) and invasive intracranial pressure measurement is excellent. ONSD reduction has the potential to indicate intracranial hypoperfusion causing delirium. In this observational study, patients aged 18 years and over who will undergo open heart surgery will be examined. ONSD will be measured using ultrasound five times in the perioperative period (t0: pre-induction, t1: post-induction, t2: onset of cardiopulmonary bypass (CPB), t3: post-CPB, and t4: post-ICU admission). The Confusion Assessment Method for the ICU (CAM-ICU) test will be used to examine delirium in the ICU. Whether the change in ONSD is an independent risk factor for delirium will be evaluated.

Interventions

DIAGNOSTIC_TESTONSD

ultrasound measurement of the optic nerve sheath diameter

Sponsors

Samsun University
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to 90 Years

Inclusion criteria

* ≥18 year old * Elective open heart surgery

Exclusion criteria

* psychiatric illness * neurological disease * ophthalmic disease * previous eye surgery * perioperative cerebrovascular disease * need for postoperative intraaortic balloon or extracorporeal support system

Design outcomes

Primary

MeasureTime frameDescription
The relationship between ONSD and postoperative delirium in cardiac surgery6 monthsPeroperatively measured ONSD will be compared with the development of postoperative delirium.
Incidence of delirium after open heart surgery6 monthsUsing the CAM-ICU test for delirium definition

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026