Depression
Conditions
Keywords
omega-3, cognition, depression
Brief summary
Depression is a serious mental illness, with persistent depression and loss of interest as the main clinical manifestations, and causes varying degrees of cognitive impairment, further leading to impaired social function, and even lead to suicidal behavior. Previous studies on the antidepressant effects of Omega-3 mainly focused on chronic effects, and there was a lack of corresponding rapid response clinical studies. Because of the nature of Omega-3 health products, no clinical adverse effects have been reported. We have previously shown that Omega-3 can produce antidepressant and cognitive improvement effects. This study will carry out different doses (low dose and high dose) and single active ingredient (EPA alone) to observe the antidepressant and cognitive improvement effects of Omega-3 in clinical patients with major depression. The antidepressant effect and cognitive improvement effect of Omega-3 will be further verified to provide evidence for future clinical application.
Interventions
DIETARY_SUPPLEMENTomega-3
supplement in the market
DIETARY_SUPPLEMENTplacebo
corn oil
Sponsors
Nanfang Hospital, Southern Medical University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* current moderate to severe depressive episode (DSM-5) * HAMD-17\>16 * 18≤Age≤45 * Never use of fluoxetine and no use of any antipsychotic and antidepressant drugs and mood stablizer at least 8 weeks * Current physical or laboratory tests show good health * negative usrine drug tests * voluntray to sign the consent form
Exclusion criteria
* treat-resistant depressive disorder * other axis I/II dignoses * MMSE≤27 recent abuse history of alcohol or drugs pregnant or breast breeding
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| depressive symptom | 40 minutes | Hamilton Depression Scale (HAMD)-17, more reduaction mean better outcome |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Cognitive performance Working memory | 4 hours | Working memory: digit span test from the Wechsler Memory Scale-Third Edition (WMS-III) |
| Cognitive performance Verbal memory | 4 hours | Verbal memory: evaluate the Logical Memory including immediate/delayed recall and recognition from the WMS-III. |
| Cognitive performance Visual memory | 4 hours | Visual memory: Rey-Osterrieth Complex Figure (ROCF) task |
| Cognitive performance | 4 hours | executive function: the Stroop Test and the Wisconsin Card Sorting Test (WCST). more improvement mean better outcome |
Countries
China
Outcome results
None listed