Anesthesia Management, Antiepileptic Drugs, Craniotomy, Metabolic Acidosis
Conditions
Keywords
Antiepileptic Drugs, Metabolic Acidosis, Anesthesia Management, Craniotomy
Brief summary
The relationship of developing metabolic acidosis with antiepleptic drugs in craniotomy operations
Detailed description
Metabolic acidosis is a life-threatening complication in the perioperative, intraoperative and postoperative period. It can cause decreased cardiac output, electrolyte imbalance, surgical bleeding and neurological complications, even coma and death in surgical patients. Topiramate and zonisamide are sulfonamide derivative compounds used in the treatment of epilepsy. It has been shown in studies that both drugs have a strong inhibition of carbonic anhydrase enzyme. Recent case reports suggest that both drugs may cause metabolic acidosis by lowering serum bicarbonate levels in some patients. Aim in this study is to determine the relationship between preoperative, intraoperative and postoperative metabolic acidosis and to emphasize the importance of anesthesia management in patients who have undergone craniotomy and use antiepileptic drugs.
Interventions
PROCEDUREArterial Blood Gas Base Deficit
The base deficit values in the preoperative, intraoperative and postoperative blood gases taken from the patients and the presence and severity of metabolic acidosis were evaluated. Metabolic acidosis severity was defined by base deficit levels: mild from -3 to -5, moderate from -5 to -10, and severe metabolic acidosis below -10.
Sponsors
Trakya University
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients undergoing intracranial surgery with craniotomy and using antiepileptic drugs * ASA I-III * Patients undergoing elective surgery
Exclusion criteria
* Patients with a surgical procedure time of more than 5 hours * Patients who received more than 2 units of blood transfusion during the operation * Patients taking other drugs that can cause metabolic acidosis * Patients with diabetes mellitus, diabetes insipidus, hepatic or renal disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Preoperative Metabolic Acidosis | Baseline | The base deficit values in the preoperative, intraoperative and postoperative blood gases taken from the patients and the presence and severity of metabolic acidosis were evaluated. Metabolic acidosis severity was defined by base deficit levels: mild from -3 to -5, moderate from -5 to -10, and severe metabolic acidosis below -10. |
| Intraoperative Metabolic Acidosis | during the operation | The base deficit values in the preoperative, intraoperative and postoperative blood gases taken from the patients and the presence and severity of metabolic acidosis were evaluated. Metabolic acidosis severity was defined by base deficit levels: mild from -3 to -5, moderate from -5 to -10, and severe metabolic acidosis below -10. |
| Postoperative Metabolic Acidosis | Day 1 | The base deficit values in the preoperative, intraoperative and postoperative blood gases taken from the patients and the presence and severity of metabolic acidosis were evaluated. Metabolic acidosis severity was defined by base deficit levels: mild from -3 to -5, moderate from -5 to -10, and severe metabolic acidosis below -10. |
Countries
Turkey (Türkiye)
Outcome results
None listed