Central Sensitization, Manual Therapy
Conditions
Keywords
central sensitization, manual therapy, non-specific low back pain
Brief summary
Central sensitization (CS) is defined as the increased responsiveness of nociceptive neurons in the central nervous system to normal or subthreshold afferent input. CS has been proposed as an underlying mechanism of chronic pain in musculoskeletal disorders including low back pain (LBP). The aim of this study is to investigate the effect of manual therapy on central sensitization in patients with nonspecific chronic LBP.
Detailed description
A total of 40 LBP patients aged between 24-64 with CSS will be randomized into two groups. The manual therapy group will receive a 4-week manual therapy (two sessions/week) plus the conventional physiotherapy program, while the control group will only receive conventional physiotherapy. Before and after the interventions pain intensity (VAS), and scores of three questionnaires: Oswestry Disability Index (ODI), Central Sensitization Inventory (CSI), and the 36-item Short Form Health Survey Questionnaire (SF-36) will be recorded.The outcomes of the study will be analyzed by appropriate statistical methods.
Interventions
OTHERmanual therapy
The manual therapy group will receive a 4-week manual therapy plus conventionel physiotherapy.
OTHERconventional physiotherapy
Control group will only receive conventionel physiotherapy intervention.
Sponsors
Atılım University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Masking description
Participant will not informed about the intervention
Intervention model description
prospective randomized controlled study
Eligibility
Sex/Gender
ALL
Age
20 Years to 64 Years
Healthy volunteers
No
Inclusion criteria
* non-spesific low back pain patients with pain longer than 12 weeks * aged between 20-64 years male and female participants
Exclusion criteria
* concomitant disease that would interfere with treatment * pregnancy * have had any spinal surgery or fracture
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pain intensity | Up to one month | A 10 cm Visual Analog Scale will be used to determine the severity of pain, with numbers ranging from 0 (no pain) to 10 (unbearable pain) |
| Central Sensitization | Up to one month | Central Sensitization Inventory (CSI) scale will be used severity of central sensitization.The total score range of the scale, which consists of a total of 25 questions, is between 0-100 points. Central sensitization with a score of 40 and above is considered positive. An increase in the total score indicates an increase in the level of central sensitization. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Oswestry Disability Index | Up to one month | Oswestry Disability Index (ODI) will be used to measure disability level |
| Health Survey | Up to one month | 36-item Short Form Health Survey Questionnaire (SF-36) will be used |
| Hospital Anxeity and depresssion | Up to one month | Hospital Anxeity and Depression Scale will be used. The cut-off points for caseness of anxiety or depression is 8/21 for anxiety or depression. For anxiety (HADS-A) this gave a specificity of 0.78 and a sensitivity of 0.9. For depression (HADS-D) this gave a specificity of 0.79 and a sensitivity of 0.83. The scores of the scale are as follows: 0-7 = Normal 8-10 = Borderline abnormal (borderline case) 11-21 = Abnormal (case) |
Countries
Turkey (Türkiye)
Outcome results
None listed