Disinfectant Causing Toxic Effect
Conditions
Brief summary
Skin antisepsis is essential in every healthcare environment. Alcohol/chlorhexidine use might disrupt skin microbiota and lead to antibiotic resistance. This study investigates honey (being natural product with many beneficial therapeutic effects) as topical skin anti-septic agent and compares it with alcohol, in terms of effectiveness and safety.
Detailed description
Recent years' investigations of the co-evolution and functional integration of the human body and its commensal microbiota have disclosed that the microbiome has a major impact on physiological functions including protection against infections. Invasive procedures such as injections, punctures or surgeries penetrate the skin's natural protective barrier, which may allow pathogenic microorganisms to enter deeper skin layers and cavities and trigger infections there. Alcohols usually in the form of 70% isopropyl alcohol or 60 to 80% ethyl alcohol, are commonly used topical disinfectants. Despite being efficiently broad-spectrum antiseptic, Alcohol shows some local hazards affecting skin integrity and microbiome. Honey has been used in wound care since ancient. It has many beneficial therapeutic effects, including anti-microbia, antioxidant, immune-modulator, wound healing and synbiotic effects . Antimicrobial agents are important in reducing the burden of infectious diseases.
Interventions
OTHERAlcohol sterilization
Sterilizing skin using alcohol
OTHERHoney sterilization
Sterilizing skin using honey
Sponsors
Ain Shams University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
2 Years to 12 Years
Healthy volunteers
Yes
Inclusion criteria
* \- Children aged from 2 to 12 years, of both sexes, and with apparently healthy skin. * Children, who did not receive any form of antimicrobial agent for at least one-week prior study.
Exclusion criteria
* \- Immuno-compromised due to diseases or drugs. * \- Children having any skin disease as eczema or others
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Assess efficacy of honey as a disinfectant in comparison to the standard disinfectant which is alcohol | 3 months | taking a swab from skin for culture of organisms after application of either alcohol or honey and compare type of organisms and number of colony forming units |
Countries
Egypt
Contacts
Primary Contactahmed badr
Backup Contactyosra awad
Outcome results
None listed