Carcinoma, Non-Small-Cell Lung
Conditions
Brief summary
This goal of this study is to describe how unintentional weight loss influences fasting and post-prandial metabolic flexibility in participants with advanced non-small cell lung cancer.
Interventions
OTHERWeight loss (%)
Change in body weight from cancer diagnosis to study enrollment
Sponsors
Pennington Biomedical Research Center
Study design
Observational model
CASE_ONLY
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age greater than or equal to 18 years * Diagnosis of non-small-cell lung cancer * Reported weight stability or loss after cancer diagnosis * Body mass index less than or equal to 35 kilograms per meter squared * Ability to provide written informed consent * Willing and able to comply with all scheduled visits, treatment plans, lab tests, and other study procedure * Allow the collection and storage of biospecimens and data for future use
Exclusion criteria
* Prior diagnosis of diabetes mellitus (type 1 or type 2) * Currently pregnant or breastfeeding * Contraindication to consuming the liquid mixed meal * Any medications affecting gastric motility * Any other condition that, in the investigator's opinion, would preclude participation or successful compliance with the protocol
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Respiratory quotient | Difference between pre- to post-prandial conditions over four hours | The respiratory quotient will be measured by indirect calorimetry before and after consumption of a liquid mixed meal |
Countries
United States
Outcome results
None listed