Functional Gastrointestinal Disorders, Infant, Newborn, Diseases
Conditions
Brief summary
There is a high prevalence of FGID among infants : 30 % for regurgitations, 20 % for colitis , 15 % for functional constipation.This represents a frequent motive for pediatrics consultation : 23 to 28 % of medical consultations in this population are consequent to gastrointestinal symptoms among infants aged under 4 months old. This can lead to numerous inappropriate or unrecommended medication prescriptions. Currently, fecal calprotectin threshold are only validated by science societies for children aged 5 years old and more. This study aims to quantify the difference of fecal calprotectin between a population of infants for whom no FGID has been finally detected, and a population of infants for whom FGID have been detected during the gastro-pediatrics consultation, , in order to later determine wether it is possible to validate a threshold in a population of infants aged under 4 months old.
Interventions
OTHERFecal calprotectin dosage
Dosing calprotectin in infants' feces + questionnaire/interview with parents
OTHERQuestionnaire and interview with parents
Dosing calprotectin in infants' feces + questionnaire/interview with parents
Sponsors
Centre Hospitalier Universitaire de Besancon
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
0 Months to 4 Months
Healthy volunteers
No
Inclusion criteria
* Infants aged under 4 months old benefiting from a special gastro-pediatrics consultation * FGID arm : infant with one or several FGID detected * Free from FGID arm : infant without any FGID detected
Exclusion criteria
* Born before 37 week of amenorrhea. * Neurologic failure, heart failure, respiratory failure, hepatic failure, pancreatic failure, renal failure, cancer or hematological malignancy. * History of enteral feeding by tube (nasogastric, nasojejunal, gastrostomy, gastrostomy-jejunostomy, jejunostomy) or parenteral feeding. * History of digestive tract surgery * Suspicion of Immunoglobulin E-mediated Cow's Milk Protein Allergy (CMPA): anaphylactic-type reaction observed within a few minutes to 2 hours after ingestion of cow's milk protein, such as pruritus, erythema, angioedema, intense abdominal pain, projectile vomiting, acute diarrhea, bronchospasm, faintness, loss of consciousness, arterial hypotension or even anaphylactic shock.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Quantification of fecal calprotectin concentration difference | 1 month | Quantification in µg/g feces of fecal calprotectin concentration difference between infants aged under 4 months old suffering from Functional Gastrointestinal disorders (FGID) and infants aged under 4 months old free from disorders |
Contacts
Primary ContactLaure CHEVENNEMENT COMMENT, Int
Outcome results
None listed