Chronic Rhinosinusitis
Conditions
Keywords
chronic rhinosinusitis with nasal polyps, chronic rhinosinusitis without nasal polyps, Otorhinolaryngologic Diseases, Respiratory Tract Diseases, Paranasal Sinus Diseases, Sinusitis, Nose Diseases, chronic rhinosinusitis (diagnosis)
Brief summary
This observatory aims to collect, as widely as possible, the Italian cases of patients with uncontrolled CRS. Patient will be enrolled by the centers of the Italian Network of Rhinosinusitis (Rhinosinusitis Italian Network: RINET), and they will be treated using a multidisciplinary team approach (allergists, otolaryngologists and pneumologists) in a real-world clinical set-up. This real-life chronic rhinosinusitis registry aims at longitudinal data collection from patients attending specialist care centres across Italy.
Detailed description
The primary objectives of the study are: * to characterize and to describe the evolution of uncontrolled Chronic Rhinosinusitis (CRS); * to facilitate and to characterize the phenotyping and endotyping of CRS; * studying the efficacy and safety of the principal therapeutic strategies and approaches to uncontrolled CRS in real-life; * supporting the development of diagnostic methodologies and innovative therapeutic strategies for CRS; * to evaluate the clinical and economic-health impact of the different therapeutic approaches (including systemic corticosteroids) used for uncontrolled CRS; * to describe factors associated with therapeutic choices and how much this factors influence natural history of the CRS; * Studying and identifying biomarkers and predictors of response to different therapies; * to increase the awareness of CRS in patients, in public opinion, in the national and international scientific community, and in the Italian clinical community of the otolaryngologists, the allergists and the pneumologists.
Interventions
OTHERSevere Uncontrolled Chronic Rhinosinusitis patients (CRS)
Obsertvation
Sponsors
Accademia Italiana di Citologia Nasale
Italian Academy of Rhinology
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Participants with a confirmed diagnosis of bilateral Chronic Rhinosinusitis that have at least three (in case of patients previously treated with surgical approaches) or four (in case of patients never treated with nasal sinus surgery) of the following criteria: * Evidence of type 2 inflammation (at least 250 blood eosinophils per microliter and / or at least 10 eosinophils / HPF from a histological sample of sinus mucosa and / or at least one finding of moderate eosinophilia on nasal cytology and / or total serum IgE \>100 IU / ml); * at least two Short courses of systemic corticosteroids or lorg-term Systemic Corticosteroids therapy for Chronic Rhinosinusitis; * Significant deterioration in the quality of life (Sinonasal Outcome Test 22 - SNOT-22\>= 40 and / or Visual Analogue Scale - Global VAS of symptoms\>= 5); * Loss of Smell (VAS for hyposmia\> = 7)
Exclusion criteria
\-
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Nasal Polyp Score | Every year to ten year | Change from baseline in total Nasal Polyp Score at year 1 to ten. The Nasal Polyp Score is the sum of the right and left nostril scores (maximum 8), as evaluated by nasal endoscopy. |
Countries
Italy
Contacts
Primary ContactEnrico Marco Heffler, MD, PhD
Backup ContactConcetta Sirena, Dr.
Outcome results
None listed