Bipolar Disorder I, Bipolar Disorder II, Schizoaffective Disorder, Depressive Type
Conditions
Brief summary
Most psychiatric research is based on the nosographic classifications used in current practice. At present, there is no diagnostic or prognostic biomarker for psychiatric pathologies commonly used in clinical practice. The study hypothesis is that peripheral inflammatory biomarkers could be common to several psychiatric disorders, in particular psychotic disorders (bipolar disorder, schizophreniform disorder, schizophrenia, depressive episode with psychotic features). The aim of this project is to set up a bio-collection of biological samples (peripheral blood samples) with associated phenotypic data (assessment of various symptoms using standardized scales in patients whose blood is sampled). The setting up of this cohort follows on from work carried out on a PsyCourse cohort also using a transdiagnostic approach in psychiatry, in order to be able to collaborate within a European research project.
Interventions
BIOLOGICALPeripheral venipuncture blood sampling, as part of standard care procedures
Collection of 36 mL of blood
OTHERInterview with a psychiatrist
Research project data collection
Sponsors
Nantes University Hospital
CR2TI, INSERM, UMR1064
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Major patient * Patient with one of the following diagnoses confirmed by a psychiatrist: * Characterized depressive episode with psychotic features, * Bipolar disorder type I * Bipolar disorder type II * Schizoaffective disorder * Schizophrenia * Schizophreniform disorder * Patient under psychiatric care at Nantes University Hospital * Patients weighing at least 45kg * Patient affiliated to a social security scheme or beneficiary of such a scheme * Patient who has given informed consent to participate in the study
Exclusion criteria
* Pregnant, * History of cancer in the last 5 years, * Vaccination within the last 4 weeks, * Acute or chronic infection, * Medical history of organ transplant, * Medical history of autoimmune disease, * Hearing impairment making it impossible to complete study questionnaires, * Patient under court protection
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Demonstration of the presence of diagnostic biomarkers and biomarkers of severity common to several psychiatric disorders. | 2 hours | Biological analysis of IBIS-PSY biocollection samples |
Secondary
| Measure | Time frame |
|---|---|
| Validation of a patient clustering method separating patients with severe symptoms from those with mild symptoms | 2 hours |
| Replication of a pan-transcriptomic study (A Transcriptome-Wide Association Study (TWAS)) | 2 hours |
| Comparison of biomarkers between different psychiatric illnesses in order to develop models based on biological data that can help the physician adjust the diagnosis | 2 hours |
Countries
France
Contacts
CONTACTAnne Sauvaget
PRINCIPAL_INVESTIGATORAnne Sauvaget
Nantes University Hospital
Outcome results
None listed