Parkinson Disease
Conditions
Keywords
Deep Brain Stimulation, Parkinson Disease, Cognitive impairment, Movement Disorders, Brain Diseases
Brief summary
The study aims to investigate cognitive impairment associated with Deep Brain Stimulation (DBS) in Parkinson's Disease patients, with a focus on identifying neurophysiology biomarkers of DBS associated cognitive changes. Using neurophysiology data recorded during DBS surgeries and post-implantation, the research intends to identify biomarkers in order to optimize electrode placement, enhance programming, and ultimately minimize DBS-related cognitive side effects.
Interventions
DEVICENeural recordings and stimulation
Neural activities from the dorsolateral prefrontal cortex and implanted DBS generator will be recorded, during resting and working memory tasks, and with the DBS target turned on and off.
Sponsors
Vanderbilt University Medical Center
United States Department of Defense
Study design
Allocation
NON_RANDOMIZED
Intervention model
SEQUENTIAL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
40 Years to No maximum
Healthy volunteers
No
Inclusion criteria
• Scheduled to undergo deep brain stimulation surgery under local anesthesia at Vanderbilt University Medical Center (Arm 1) * Active deep brain stimulation system with implantable pulse generator capable of recording local field potentials (Arm 2) * Diagnosis of Parkinson's disease as determined by a movement disorders specialist neurologist * Age at least 18 * Able to participate in intraoperative testing * English speaking
Exclusion criteria
* Age less than 18 * Not able to participate in intraoperative testing (ex unable to comprehend instructions or follow directions)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Determination of DLPFC beta power a biomarker of DBS associated cognitive impairment in the acute stimulation setting | Baseline to end of Deep Brain Stimulation (DBS), approximately 3-4 hours | Working memory tasked will be conducted during surgery, and local field potentials (LFPs) will be recorded from the DLPFC both at rest and during task execution, under two conditions: with and without stimulation. |
| Determination of STN local field potential biomarkers of DBS mediated cognitive impairment following chronic stimulation | 1 hour | Local field potentials will be recorded from subthalamic nucleus or globus pallidus internus in patients with an existing DBS system with implantable pulse generator capable of recording local field potentials. Recordings will be performed at rest and during a working memory task, with DBS on and off. |
Countries
United States
Contacts
PRINCIPAL_INVESTIGATORSarah K Bick, MD
Vanderbilt University Medical Center
Outcome results
None listed