ARDS: Acute Respiratory Distress Syndrome, Covid19
Conditions
Brief summary
The goal of this observational study is to learn about the effect of steroid therapy in patients with COVID-19 ARDS. The main questions it aims to answer are: * Differences between patients with COVID-19 ARDS before and after steroid treatment in BALF single cell landscape, as well as patients with different prognosis. * Differences between COVID-19 and non COVID-19 ARDS patients in BALF single cell landscape. Participants will Choose whether to use or not to utilize steroid treatment based on conditions.
Detailed description
Collect BALF from COVID-19 and non-COVID-19 ARDS patients both before and during remission, then perform single-cell sequencing.
Interventions
DRUGsteroid
Moderate- or high-dose steroids
Sponsors
Peking Union Medical College Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Inclusion criteria
* Severe ARDS patients
Exclusion criteria
* None
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| single-cell analysis in BALF before treatment | before treatment in ICU | collect BALF before and during treatment and perform single-cell sequencing |
| single-cell analysis in BALF after treatment | After treatment in ICU for 1-4 weeks | collect BALF before and during treatment and perform single-cell sequencing |
Countries
China
Outcome results
None listed