Gastro Intestinal Bleeding
Conditions
Brief summary
The aim of this retrospective study is to investigate the relationship between factor XIII activity and the outcome of gastrointestinal bleedings. Since factor XIII is of great importance in haemostasis and plays a key role in stabilizing the fibrin clot, it can be assumed that a deficiency of factor XIII leads to an unfavorable course of gastrointestinal bleedings. Our hypothesis is that early detection of such a deficiency can prevent a more severe course and that substitution of factor XIII contributes to faster cessation of bleeding, improves patient outcome and reduces the number of red cell concentrates required.
Interventions
DRUGFactor XIII Injection
Patients could have had an Factor XIII Injection in clinical routine
Sponsors
Medical University of Graz
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 100 Years
Healthy volunteers
No
Inclusion criteria
* Age over 18 years * Confirmed diagnosis of gastrointestinal bleeding * Assessment of factor XIII activity during the gastrointestinal bleeding episode
Exclusion criteria
* Age under 18 years * Diagnosis of hemophilia A or B or other congenital coagulation disorders
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Red cell concentrates | 1 year | Number of red cell concentrates transfused during the hospital stay caused by the gastrointestinal bleeding episode |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Hospitalization | 1 year | Length of the hospital stay caused by the gastrointestinal bleeding episode |
| Interventions | 1 year | Number of endoscopic, radiological, and surgical interventions for bleeding treatment within the hospital stay caused by the gastrointestinal bleeding episode |
| Mortality | 1 year | In hospital-mortality during the hospital stay caused by the gastrointestinal bleeding episode |
Countries
Austria
Outcome results
None listed