Hepatopulmonary Syndrome (HPS)
Conditions
Brief summary
Hepatopulmonary syndrome (HPS) has unknown pathogenesis, limited treatment and poor prognosis. The onset of HPS is insidious and easy to be ignored. Many liver diseases such as cirrhosis and related complications are the core characteristics of Beijing You 'an Hospital, but the clinical characteristics of HPS patients in the center are still unclear. The investigators plan to make the diagnosis of HPS among chronic liver disease patients in the hospital according to the diagnostic criteria of HPS proposed in the Practice Guidelines of the International Society of Liver Transplantation in 2016, collect clinical data of HPS participants, evaluate the severity, analyze and summarize clinical characteristics, and conduct management and follow-up. At the same time, The investigators collect blood samples for proteomics tests. In order to improve the diagnosis and treatment level of HPS.
Detailed description
At present, the mechanism of hepatopulmonary syndrome is not clear. The researchers plan to use the extracted plasma for detection, protein extraction and quality control, and then proteolytic hydrolysis, computer detection, and bioinformatics analysis.
Interventions
BIOLOGICALProteomic sequencing
Proteomic sequencing, bioinformatics analysis，find abnormal indicators between two groups
Sponsors
Sun Jie
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 100 Years
Healthy volunteers
No
Inclusion criteria
* chronic hepatitis Agreed to venous blood collection
Exclusion criteria
* pneumonia, pulmonary vascular disease, interstitial pulmonary disease, COPD, bronchial asthma, lung cancer and other primary pulmonary diseases, acute upper gastrointestinal bleeding.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Proteomic results of participants | April 1,2024 | Qualitative and quantitative analysis of proteome |
Countries
China
Outcome results
None listed