Fluid Responsiveness, Hemodynamic Monitoring
Conditions
Keywords
Internal Jugular Venous Distensibility Index, Innominate Venous Flow Patterns
Brief summary
The measurement of internal jugular vein distensibility index corresponds to the measurement of stroke volume using trans-thoracic Doppler echocardiography in assessing the response to fluid administration in elective surgical patients.
Interventions
DEVICEUltrasonography of Internal Jugular Vein
Non invasive monitoring of fluid responsiveness
DEVICEDoppler Echocardiograhy
Non invasive monitoring of fluid responsiveness
Sponsors
Indonesia University
Study design
Observational model
CASE_ONLY
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
1. Utilizing intraoperative mechanical ventilation with a tidal volume of 8 ml/kg (PBW). 2. ASA physical status 1-3. 3. Mongoloid ethnicity. 4. Willing to participate in the research and sign the informed consent.
Exclusion criteria
1. Patients with symptoms and signs of fluid overload, such as pulmonary edema, pleural effusion, ascites, and peripheral edema. 2. Patients with chronic or acute kidney dysfunction, renal replacement therapy history, and/or oliguria (urine output \<0.5 ml/kg/hour). 3. Patients with cardiovascular diseases, including heart failure, cardiac arrhythmias, moderate-to-severe valvular abnormalities, a history of angina/myocardial infarction, pulmonary hypertension, and peripheral artery disease. 4. Patients with anatomical abnormalities in the neck and chest region that make it impractical to perform jugular vein ultrasound and transthoracic echocardiography. 5. Jugular vein thrombosis. 6. Superior vena cava syndrome. 7. Placement of jugular vein catheter. 8. Body mass index (BMI) greater than 30.0 kg/m2. 9. Patients with contraindications to the use of muscle relaxants. 10. Patients with lung hyperinflation and pleural effusion. Drop out criteria: 1. Patients who wish to withdraw from the study. 2. Post-anesthesia induction complications and emergencies. 3. Transthoracic echocardiography provides a less representative image due to difficult acoustic window.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| IJV distensibility index correlation to fluid responsiveness | 1 day | Correlation between IJV distensibility index and fluid responsiveness defined as increase of stroke volume more than 10% after fluid challenge |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Comparison of IJV distensibility index in fluid responders and non-fluid responders. | 1 day | — |
| Detection of sensitivity, specificity, positive predictive value, negative predictive value, and best cut off value of IJV distensibility index to predict fluid responsiveness | 1 day | By ROC curve and Youden index |
| Correlation of IJV distensibility index and stroke volume | 1 day | — |
| Innominate vein flow velocity correlation to fluid responsiveness | 1 day | Correlation between Innominate vein flow velocity and fluid responsiveness defined as increase of stroke volume more than 10% after fluid challenge |
Countries
Indonesia
Outcome results
None listed