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Multimodal Machine Learning for Auxiliary Diagnosis of Eye Diseases

Multimodal Machine Learning for Auxiliary Diagnosis of Eye Diseases Using ChatGPT-based Natural Language Processing and Image Processing Techniques

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT05930444
Enrollment
9825
Registered
2023-07-05
Start date
2023-07-21
Completion date
2024-03-31
Last updated
2024-11-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Eye Diseases

Brief summary

With rapid advancements in natural language processing and image processing, there is a growing potential for intelligent diagnosis utilizing chatGPT trained through high-quality ophthalmic consultation. Furthermore, by incorporating patient selfies, eye examination photos, and other image analysis techniques, the diagnostic capabilities can be further enhanced. The multi-center study aims to develop an auxiliary diagnostic program for eye diseases using multimodal machine learning techniques and evaluate its diagnostic efficacy in real-world outpatient clinics.

Interventions

DIAGNOSTIC_TESTMultimodal Machine Learning Program for Auxiliary Diagnosis of Eye Diseases

Patients presenting with eye-related chief complaints initially complete a mobile phone application. This application utilizes patient medical history and relevant images (such as selfies and photos from eye examinations) to provide intelligent diagnosis. The diagnosis remains undisclosed to the patients. Subsequently, patients seek medical attention and undergo clinical examination by a skilled clinician. The clinical diagnosis is subsequently reviewed by a second experienced clinician. If the diagnoses align, it is considered the gold standard. In cases of discrepancy, the consensus reached by the two clinicians becomes the gold standard.

Sponsors

The Affiliated Eye Hospital of Nanjing Medical University
CollaboratorUNKNOWN
Suqian First Hospital
CollaboratorOTHER
Eye & ENT Hospital of Fudan University
Lead SponsorOTHER

Study design

Observational model
OTHER
Time perspective
CROSS_SECTIONAL

Eligibility

Sex/Gender
ALL
Age
2 Months to No maximum
Healthy volunteers
Yes

Inclusion criteria

* Informed consent obtained; * Participants should be able to have Chinese as their mother tongue, and be sufficiently able to read, write and understand Chinese; * For normal participants: individuals should have no concerns related to their eyes. * For participants with eye-related chief complaints: individuals should have specific concerns or issues related to their eyes.

Exclusion criteria

* Incomplete clinical data to support final diagnosis; * Patients who, in the opinion of the attending physician or clinical study staff, are too medically unstable to participate in the study safely.

Design outcomes

Primary

MeasureTime frameDescription
Diagnostic accuracy of multimodal machine learning programfrom July 2023 to March 2024For each patient, the diagnoses generated by the multimodal machine learning program and the clinical diagnosis provided by skilled clinicians were documented and compared. Consistency between the two diagnoses indicates the program's precision in clinical practice.

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 9, 2026