Diabetes
Conditions
Keywords
Diabetes
Brief summary
The goal of this clinical trial is to test microwave metamaterial glucose sensor on blood samples. It means to compare the results of glucose values obtained by microwave metamaterial sensor and by standard biochemical analyzer.
Detailed description
Participants will include physiological and pathological populations. Participants donate approximately 5 ml of blood sample. Three sample tubes will be collected from ten adult participants. In the first test tube, the blood glucose content will be determined by a validated biochemical analyzer (Roche, Switzerland). In the remaining volume of the blood sample, the dielectric parameters (relative permittivity and conductivity) will be estimated using a coaxial probe (Keysight, USA). Microwave metamaterial sensors with 5, 7 and 9 unit cells will be loaded with blood samples and the specific scattering matrices will be obtained using a vector network analyzer. The main monitored outcome measure will be the phase of parameter S21.
Interventions
DIAGNOSTIC_TESTIn vitro full blood diagnostic test.
Participant will donate approximately 5 ml blood sample. Later in a laboratory the sample will be processed in the microwave metamaterial sensor for non invasive blood glucose monitoring and standard biochemical analyzer. Specific dielectric properties and scattering parameters will be measured for blood glucose level determination.
Sponsors
Czech Technical University in Prague
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* blood glucose can be measured with standard biochemical analyzer
Exclusion criteria
* minimum age limit 18 years
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Phase shift of scattering parameter S21 | When blood sample is filled into sensor chamber within 24 hours from blood collection. | The proposed microwave sensor uses a section of planar metamaterial transmission line operating at GHz frequencies. The speed of electromagnetic wave propagation through the sample is affected by the concentration of glucose. The delay can be expressed in degrees (°) as the phase of the complex S21 parameter. |
| Blood glucose concentration | When blood sample is processed in biochemical analyzer within 24 hours from blood collection. | Molar mass of glucose dissolved in liquid blood sample expressed as molar concentration (mmol/l). |
| Blood sample specific electrical conductivity | When blood sample is presented into the co-axial probe container within 24 hours from blood collection. | The specific electrical conductivity (S/m) of the blood samples will be measured using a coaxial probe. |
| Blood sample relative permittivity | When blood sample is presented into the co-axial probe container within 24 hours from blood collection. | The relative permittivity (-) of the blood samples will be measured using a coaxial probe. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Sensor sensitivity | After primary data acqiusition. | Present the relation between the value of he Phase shift of scattering parameter S21 and Blood glucose concentration. |
| Mathematical model of blood glucose dependence on blood dielectric parameters | After primary data acqiusition. | The mathematical model describing which combination of dielectric parameter values (specific electrical conductivity and relative permittivity) corresponds to the certain blood glucose level. |
Countries
Czechia
Outcome results
None listed