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Buccal Mucosal Graft for Onlay Ureteroplasty in the Management of Proximal Ureteral Stricture

Buccal Mucosal Graft for Onlay Ureteroplasty in the Management of Proximal Ureteral Stricture

Status
Recruiting
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT05928364
Enrollment
100
Registered
2023-07-03
Start date
2022-01-01
Completion date
2024-10-01
Last updated
2024-08-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Stricture Ureter

Keywords

Buccal mucosa, Stricture, ureteroplasty

Brief summary

Onlay uretroplasty with either grafts or flaps has been attempted by many reconstructive urologists, ln particular buccal mucosa graft (BMG) ureteroplasty has been reported by many centers and has shown its feasibility and safety

Detailed description

In cases of long segment upper ureteral stricture, more advanced surgical techniques, such as renal mobilization and downward nephropexy, ileal ureter replacement, transureteroureterostomy, and autotransplantation of the kidney, are necessary to provide a tension-free anastomosis. Autotransplantation of the kidney needs more efforts, more experts and may lead to significant renovascular complications. Also, there is severe metabolic and intestinal complications are associated with using of long intestinal segment in the management of ureteral stricture \[9\]. These previous side effects and difficulties make the management of long upper and middle ureteral strictures more complicated and indicate other lines of management urgently. Even the ureteral stricture still not patent enough to drain urine but still, we can use it as a ureteral plate with little affection of its vascularity. Based on this theory an onlay repair technique was emerged. Onlay uretroplasty with either grafts or flaps has been attempted by many reconstructive urologists, ln particular buccal mucosa graft (BMG) ureteroplasty has been reported by many centers and has shown its feasibility and safety.

Interventions

PROCEDUREBuccal mucosa for proximal ureter stricture

Patients with inclusion criteria of uretral stricture will be treated with open uretroplasty with buccal graft and omental wrapping

Sponsors

Al-Azhar University
Lead SponsorOTHER

Study design

Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE

Intervention model description

Patients with inclusion criteria of uretral stricture will be treated with open uretroplasty with buccal graft and omental wrapping

Eligibility

Sex/Gender
ALL
Healthy volunteers
No

Inclusion criteria

* Proximal ureteral stricture or uretropelvic junction obstruction (UPJO) which are not amenable for primery anastmosis.

Exclusion criteria

* Buccal graft contraindications as i. Active oral infections ii.Oral cancers like cancers of lips, tongue or cheeks.

Design outcomes

Primary

MeasureTime frameDescription
Restoration of ureteric patency.6 months post-operativeRestoration of ureteric patency as assessed by contrast study (intravenous urography) and ureteroscope.

Secondary

MeasureTime frameDescription
Pain relief after surgery6 months post-operativeRelief of pain measured by Visual Analog Score for pain

Countries

Egypt

Contacts

Primary ContactMohamed F Salman, MD
prof_mohamed_fawzy@yahoo.com+201111788996

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026