Healthy
Conditions
Keywords
articular cartilage, walking exercise, sCOMP, PIIANP
Brief summary
The serum concentration of cartilage oligomeric matrix protein (sCOMP) has been considered a mechano-sensitive biomarker of articular cartilage turnover, and N-propeptide of type II collagen (PIIANP) is a proposed biomarker of type II collagen synthesis. Few studies have investigated both the anabolic and turnover response of articular cartilage as a result of acute changes in body weight mass during exercise. Using a repeated measures cross-over design, fifteen healthy adults (age 18-30 years) performed three, 30-minute bouts of treadmill walking exercise under 3 loading conditions: (1) control (no alteration to body mass); (2) loaded (12% increase in body mass using a weighted vest); and (3) unloaded (12% decrease in body mass using lower body positive pressure). Venous blood was collected before, immediately after, and 15 and 30 minutes after exercise to investigate cartilage turnover (sCOMP) and anabolism (PIIANP).
Interventions
OTHERControl Condition
Control (no alteration to body mass).
OTHER+12% Body Mass
Loaded walking exercise (12% increase in body mass using a weighted vest).
OTHER-12% Body Mass
Unloaded walking exercise (12% decrease in body mass using lower body positive pressure).
Sponsors
University of Manitoba
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 30 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy * 18-30 years old
Exclusion criteria
* Traumatic injury to the lower extremity in the past year * Hip, knee, or ankle surgery * Radiographic evidence of joint degeneration * Cardiovascular disease * Ankylosing spondylitis * Psoriatic arthritis * Chronic reactive arthritis * Renal problems requiring peritoneal dialysis or hemodialysis * Not currently using any prescription or non-prescription medications and/or nutritional supplements
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Serum cartilage oligomeric matrix protein (sCOMP) | sCOMP was measured at baseline, immediately post, and 15- and 30-minutes post exercise. | The systemic blood serum concentration of sCOMP was evaluated in all participants under the 3 conditions in a crossover trial. |
| N-propeptide of type II collagen (PIIANP) | PIIANP was measured at baseline, immediately post, and 15- and 30-minutes post exercise. | The systemic blood serum concentration of PIIANP was evaluated in all participants under the 3 conditions in a crossover trial. |
Countries
Canada
Outcome results
None listed