Acute Kidney Injury
Conditions
Keywords
Neuronal Guidance Protein, Acute Kidney Injury
Brief summary
Acute kidney failure remains one of the most challenging entities to diagnose in clinical medicine, especially in the field of intensive care. The diagnosis of acute kidney injury is based solely on urine output and serum creatinine, both of which could also be influenced by other factors. A more sensitive and faster diagnostic option would not only be desirable but of utmost clinical importance. Therefore, the investigators aim to identify Neuronal Guidance Proteins (NGPs) as potential biomarkers for the identification and early detection of AKI with this investigation. This investigation aims to identify the possibility of diagnosing acute kidney injury, the subsequent validation of a potential biomarker will then have to take place in a multicenter study approach: Data in preclinical mouse models suggest that SEMA7A as one of the NGPs could be valuable as a biomarker, the study now aims to attempt a preliminary survey in humans and measure various NGPs.
Interventions
None listed
Sponsors
University Hospital Tuebingen
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* Patients undergoing cardiac surgery * written consent
Exclusion criteria
* no written consent possible * Polytrauma, severe burns * Immunosuppression * Pregnancy * Diagnosis of Hepatitis B, Hepatitis C, and/or HIV * Sepsis * Pre-existing kidney damage
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| AKI | 1-7 days | Development of AKI after cardiac surgery |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| NGP | 1-7 days | Concentration of NGPs in Blood and Urine |
Contacts
Primary ContactAndreas Körner, MD
Backup ContactMichael Koeppen, MD
Outcome results
None listed