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Effects of Preoperative Rehabilitation on Tendon Healing, Bone Mineral Density, and Cartilage After ACLR and Patellar Dislocation

A Study on the Effect of Exercise Rehabilitation on Bone Mineral Density, Reconstruction Ligament Tendon Bone Healing and Cartilage After ACL Rupture and Patellar Dislocation

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT05924178
Enrollment
60
Registered
2023-06-29
Start date
2023-07-10
Completion date
2026-06-01
Last updated
2026-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anterior Cruciate Ligament Rupture

Brief summary

To explore the effect of preoperative exercise rehabilitation on bone mineral density, tendon bone healing, change of cartilage, and gait feature in patients with anterior cruciate ligament rupture.

Detailed description

Anterior Cruciate Ligament (ACL) injury is one of the most common sports injuries. It is a serious knee injury. The fracture of ACL can cause functional instability of knee joint, damage of meniscus and articular cartilage, and even induce knee osteoarthritis and other diseases. It has great influence on knee joint and even lower limb function of patients. Arthroscopic ACL reconstruction has become the first choice in clinical treatment of ACL fracture. ACL fracture can cause local knee joint osteoporosis, and reconstruction surgery can also affect tendon bone healing, bone canal enlargement, rehabilitation period, gait, articular cartilage degradation, etc. This study intends to conduct preoperative rehabilitation intervention for young people with anterior fork rupture, and explore the effects of exercise rehabilitation on knee bone mineral density, muscle strength, proprioceptive ability and other aspects after ACL rupture, as well as the effects of knee bone mineral density, tendon bone healing, bone tunnel aperture, motor function, gait characteristics and cartilage degradation after reconstruction.

Interventions

BEHAVIORALexercise rehablitation

Preoperative exercise rehabilitation in experimental group was performed.

BEHAVIORALroutine treatment

The control group receives conventional treatment preoperative.

Sponsors

Peking University Third Hospital
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)

Eligibility

Sex/Gender
ALL
Age
18 Years to 45 Years
Healthy volunteers
No

Inclusion criteria

1. Age 18\~40 years old, diagnosed ACL rupture or Patellar Dislocation by MRI; 2. The first unilateral ligamenta reconstruction at our hospital;

Exclusion criteria

1. Be older than 40 years, or less than 18 years old 2. Severe injury to other knee ligaments 3. History of knee trauma

Design outcomes

Primary

MeasureTime frameDescription
Grade of tendon bone healingAt 6 monthes post operation.tendon bone healing by knee MRI
balanced capacityAt preoperative.Y balance test
knee T1 rho valueAt 6 months post operation.knee T1 rho value by functional MRI
knee T2 valueAt 6 months post operation.knee T2 rho value by functional MRI
knee extension anglesAt 6 months post operation.Three-dimensional gait analysis system and plantar pressure were used during walking, running, cutting and jumping
Graft maturityAt 6 monthes post operation.tendon bone healing by knee MRI
bone mineral densityAt preoperative.bone mineral density by knee DEX
isokinetic muscle strengthAt preoperative.Knee isokinetic strength test

Secondary

MeasureTime frameDescription
The HU value of CTat pre-operationCT test
Thigh CircumferenceAt 2 years post operation.the circumference of 15 cm above the superior aspect of the patella
Single-Leg HopAt 1 year post operation.a maximal-distance hop

Countries

China

Contacts

CONTACTShuang Ren
xixishuang123@126.com17610252992

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Jul 2, 2026