Heat Stroke
Conditions
Keywords
heat stroke, cooling blanket, cooling rate, outcomes
Brief summary
The goal of this clinical trial is to test the cooling effect of cooling blanket in patients with heat stroke. The main questions it aims to answer are: * the cooling rate of cooling blanket in patients with heat stroke * the relationship between cooling blanket and outcomes in patients with heat stroke Participants will accept the cooling blanket or non-cooling blanket according to the randomization group. Researchers will compare cooling rate and outcomes to see if the cooling blanket can accelerate the cooling speed and improve the prognosis of patients in heat stroke.
Interventions
DEVICEcooling blanket
On the basis of the cooling methods of non-cooling blanket group, combine the cooling blanket to cool down. The cooling blanket is required to be activated within 30min after admission. The blanket temperature will be set at 4-10℃, and the target body temperature is 38℃.
DEVICEnon-cooling blanket
Patients do not receive cooling blanket according to randomization. Cooling body temperature by: control the temperature of the emergency room to 20-24℃, 4℃ fluid infusion, ice packs, evaporation, convection,etc.
Sponsors
Second Affiliated Hospital, School of Medicine, Zhejiang University
Yiwu Central Hospital
Jinhua Municipal Central Hospital
Jinhua People's Hospital
Lanxi People's Hospital
Yongkang No.1 People' s Hospital
Dongyang People's Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* ≥ 18 years old * diagnosed as heat stroke * informed consent of patients or family members
Exclusion criteria
* need immediate cardiopulmonary resuscitation * body temperature \<39.5℃ on admission * with the underlying disease of severe organ damage * pregnant women
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| 0.5-hour temperature reduction | 0.5 hours | Calculated as the difference between initial core temperature and core temperature at 0.5 hours after admission. |
| Body temperature of 0.5 hours | 0.5 hours after admission to emergency department | Body temperature of 0.5 hours referred to the temperature value obtained 5 min before and after 0.5 hour. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Body temperature of 2 hours | 2 hours | Body temperature of 2 hours referred to the temperature value obtained 20 min before and after 2 hours. |
| incidence of organ damage | up to 90 days | number of participants with organ damage, including but not limited to brain, lung, heart, kidney, liver, and coagulation function |
| length of ICU stay | up to 90 days | The length patient stay at ICU |
| in-hospital mortality | up to 90 days | number of participants dead in-hospital |
Countries
China
Contacts
CONTACTXiuqin Feng
CONTACTLan Chen
PRINCIPAL_INVESTIGATORLan Chen
Second Affiliated Hospital, School of Medicine, Zhejiang University
Outcome results
None listed