Antidiabetic Drugs, Type 2 Diabetes
Conditions
Brief summary
The purpose of this study is to determine whether the combination of SGLT2i and ARNI in type 2 diabetic patients with combined albuminuria could reduce urinary protein more significantly than single agent.
Detailed description
This project is a single-center retrospective cohort study to obtain the biochemical index levels of urinary albumin creatinine ratio, urinary protein creatinine ratio, blood renal function, blood lipids, and blood glucose at the immediate, 3rd, 6th, and 12th month of cohort inclusion in each group of patients.
Interventions
None listed
Sponsors
Peking University Third Hospital
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Inclusion criteria
* Age greater than or equal to 18 years * Clinical diagnosis of type 2 diabetes mellitus * Immediate urine albumin creatinine ratio greater than 30mg/g * Signed informed consent and available for follow-up
Exclusion criteria
* severe renal insufficiency, i.e. eGFR ≤ 30ml/min/1.75m2 * clinical diagnosis of various acute and chronic urinary tract infections * combined with various serious infectious diseases * combined with acute complications of diabetes mellitus * end-stage malignancy * pregnancy and lactation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| urinary protein changes | 2023.03-2024.03 | to determine whether the combination of SGLT2i and ARNI in type 2 diabetic patients with combined albuminuria could reduce urinary protein more significantly than single agent. |
Countries
China
Outcome results
None listed