Fetal Acidemia
Conditions
Keywords
high-flow nasal oxygen, cesarean section, oxygen, umbilical artery, acidemia
Brief summary
The study propose that the using the high-flow nasl oxygen to provide oxygen for maternal can improve the fetal acidemia and the neonatal outcomes during cesarean section with combined spinal-epidural anesthesia.
Detailed description
Maternal oxygen supplementation is widely used intrauterine resuscitation technique in clinical, which can improve fetal oxygenation and prevent fetal acidemia. The incidence of hypotension is high in cesarean section with combined spinal-epidural anesthesia. Hypotension contributes to insufficient perfusion of uterus and placenta, resulting in decreased fetal oxygen supply and neonatal acidemia. High flow nasal oxygen have a better improvement oxygenation of patients by providing high flow oxygen airflow with heating and humidification through nasal cannula.
Interventions
DEVICEOptiflow high-flow nasal cannula system
Using the Optiflow high-flow nasal cannula system to supply oxygen for maternal.
Sponsors
Beijing Tongren Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* An elective cesarean section in Beijing Tongren Hospital * ≥37 weeks' gestation * American society of Aneshesiologists（ASA） I-III * Aged 18 to 45 years old * The fasting time is 6-8h, and the water restriction time is ≥2h * Anesthesia: combined spinal-epidural anesthesia * Agree to the study and sign the informed consent
Exclusion criteria
* Fetal or placental abnormalities are known * Maternal has complications * Maternal BMI ≥40 kg/m2 * History of difficult intubation or known difficult airway * Contraindications for HFNO such as nasal lesions or structural changes * Gastric reflux disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| umbilical artery lactate, mmol/L | the fetal delivery | mmol/L |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| umbilical artery pH value | the fetal delivery | unitless |
| umbilical artery oxygen partial pressure(PO2) | the fetal delivery | mmHg |
| umbilical artery partial pressure of carbon dioxide(PCO2) | the fetal delivery | mmHg |
| umbilical artery base excess(BE), mmol/L | the fetal delivery | mmol/L |
| the incidence of pH<7.20 and pH<7.10 | the fetal delivery | percentage |
Countries
China
Outcome results
None listed