Amenorrhea Secondary
Conditions
Brief summary
The purpose of this study is to analyze AMH levels in patients with prolonged FHA (more than 2 years). Based on previous studies, we can assume that prolonged FHA may mimic a condition of primary hypogonadotropic hypogonadism, due to a lasting interruption of gonadotropin release. Furthermore, after the resumption of the spontaneous menstrual cycle, we will reanalyze AMH levels, which we hypothesize to find higher. If our hypotheses are confirmed correct, we could support the thesis that AMH is not a good index of ovarian reserve in patients with functional hypothalamic amenorrhea.
Interventions
DIAGNOSTIC_TESTvenous sampling
venous sampling
Sponsors
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
15 Years to 34 Years
Inclusion criteria
* Women aged 15-34 years. * Diagnosis of functional hypothalamic amenorrhea (for at least 2 years). * Signature of informed consent.
Exclusion criteria
* Polycystic ovary syndrome * Taking oral contraceptives in the previous three months * Other clinically relevant endocrinopathies * positive MAP-test (Medroxyprogesterone acetate test) * Estroprogestin replacement therapy * Autoimmune disorders * Failure to sign informed consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| AMH assay | 12 months | Check serological AMH levels in patients with FHA for at least 2 years and compare them with AMH levels in healthy women. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| To correlate AMH levels with other parameters | 12 months | Correlate serologic AMH levels with antral follicle count (AFC). Verify serologic AMH levels in previously FHA patients after resumption of spontaneous menstruation, i.e., at 6 months |
Countries
Italy
Outcome results
None listed